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Rabbit Anti-CLDN6 Recombinant Antibody (EG724) (CBMAB-EN878-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG724
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 119-219 of human Claudin 6.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000-1:5,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.3, 50% glycerol, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
1.7 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 6
Introduction
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Entrez Gene ID
Human9074
Mouse54419
Rat287098
UniProt ID
HumanP56747
MouseQ9Z262
RatB4F7F0
Alternative Names
Claudin 6; Skullin; Claudin-6;
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-160
Helical: 161-181
Cytoplasmic: 182-220
More Infomation

Matsuzaki, J., Lele, S., Odunsi, K., & Tsuji, T. (2022). Identification of Claudin 6-specific HLA class I-and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer. Oncoimmunology, 11(1), 2020983.

Du, H., Yang, X., Fan, J., & Du, X. (2021). Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation. Molecular Medicine Reports, 24(3), 1-9.

Gao, P., Peng, T., Cao, C., Lin, S., Wu, P., Huang, X., ... & Wu, P. (2021). Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. Frontiers in Genetics, 12.

Kojima, M., Sugimoto, K., Tanaka, M., Endo, Y., Kato, H., Honda, T., ... & Chiba, H. (2020). Prognostic significance of aberrant claudin-6 expression in endometrial cancer. Cancers, 12(10), 2748.

Kojima, M., Sugimoto, K., Kobayashi, M., Ichikawa-Tomikawa, N., Kashiwagi, K., Watanabe, T., ... & Chiba, H. (2021). Aberrant Claudin-6–Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α. Molecular Cancer Research.

Kohmoto, T., Masuda, K., Shoda, K., Takahashi, R., Ujiro, S., Tange, S., ... & Imoto, I. (2020). Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer. Gastric Cancer, 23(3), 403-417.

Lewis, J. B., Bodine, J. S., Gassman, J. R., Muñoz, S. A., Milner, D. C., Dunaway, T. M., ... & Reynolds, P. R. (2018). Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation. Environmental Science and Pollution Research, 25(18), 18179-18188.

Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X., ... & Quan, C. (2017). Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncology reports, 38(2), 875-885.

Bekki, H., Yamamoto, H., Takizawa, K., Iwasaki, T., Otsuka, H., Yamada, Y., ... & Oda, Y. (2017). Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. Pathology-Research and Practice, 213(6), 674-679.

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For research use only. Not intended for any clinical use.

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