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Mouse Anti-CLDN6 Recombinant Antibody (CBFYC-1908) (V2LY-1206-LY55)


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Published Data
V2LY-1206-LY55-1
Mouse Anti-CLDN6 Recombinant Antibody (CBFYC-1908) (V2LY-1206-LY55) in IHC
Immunohistochemistry in esophageal adenocarcinoma with expression of fetal-gut cell markers; (a) Claudin-6 expression on tumour cells, (b) glypican 3 expression on tumor cells, (c) SALL4 expression on the nucleus of the tumor cells, (d) CK7 loss of the tumour cells, (e) AFP expression on tumour cells (lymph node metastasis), (f) SMARCA2 loss of tumour cells (tumor nuclei in pale blue without expression of SMARCA2 protein and co-existing lymphocytes and other stroma cells within the tumor show preserved SMARCA2 expression). ...View More
Kraemer, M., Zander, T., Alakus, H., Buettner, R., Lyu, S. I., Simon, A. G., ... & Quaas, A. (2024). Fetal gut cell-like differentiation in esophageal adenocarcinoma defines a rare tumor subtype with therapeutically relevant claudin-6 positivity and SWI/SNF gene alteration. Scientific Reports, 14(1), 13474.
Distributed under Open Access license CC BY 4.0, without modification.
V2LY-1206-LY55-2
Mouse Anti-CLDN6 Recombinant Antibody (CBFYC-1908) (V2LY-1206-LY55) in Immunoblot
Il22-/- mice were infected and colon epithelial cell lysates were derived and IB for indicated claudins, with β-actin as a loading control. ...View More
Xia, X., Liu, Y., Hodgson, A., Xu, D., Guo, W., Yu, H., ... & Wan, F. (2019). EspF is crucial for Citrobacter rodentium-induced tight junction disruption and lethality in immunocompromised animals. PLoS pathogens, 15(6), e1007898.
Distributed under Open Access license CC BY 4.0, without modification.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-1908
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
Amino acids 191-220 at the C-terminus of claudin-6 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Claudin 6
Entrez Gene ID
Human9074
Mouse54419
Rat287098
UniProt ID
HumanP56747
MouseQ9Z262
RatB4F7F0
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.

(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
Biological Process
Bicellular tight junction assembly Source: GO_Central
Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
Cell adhesion Source: GO_Central
Cellular Location
Cell membrane; Tight junction
Topology
Cytoplasmic: 1-7
Helical: 8-28
Extracellular: 29-81
Helical: 82-102
Cytoplasmic: 103-116
Helical: 117-137
Extracellular: 138-160
Helical: 161-181
Cytoplasmic: 182-220
More Infomation

Matsuzaki, J., Lele, S., Odunsi, K., & Tsuji, T. (2022). Identification of Claudin 6-specific HLA class I-and HLA class II-restricted T cell receptors for cellular immunotherapy in ovarian cancer. Oncoimmunology, 11(1), 2020983.

Du, H., Yang, X., Fan, J., & Du, X. (2021). Claudin 6: Therapeutic prospects for tumours, and mechanisms of expression and regulation. Molecular Medicine Reports, 24(3), 1-9.

Gao, P., Peng, T., Cao, C., Lin, S., Wu, P., Huang, X., ... & Wu, P. (2021). Association of CLDN6 and CLDN10 With Immune Microenvironment in Ovarian Cancer: A Study of the Claudin Family. Frontiers in Genetics, 12.

Kojima, M., Sugimoto, K., Tanaka, M., Endo, Y., Kato, H., Honda, T., ... & Chiba, H. (2020). Prognostic significance of aberrant claudin-6 expression in endometrial cancer. Cancers, 12(10), 2748.

Kojima, M., Sugimoto, K., Kobayashi, M., Ichikawa-Tomikawa, N., Kashiwagi, K., Watanabe, T., ... & Chiba, H. (2021). Aberrant Claudin-6–Adhesion Signaling Promotes Endometrial Cancer Progression via Estrogen Receptor α. Molecular Cancer Research.

Kohmoto, T., Masuda, K., Shoda, K., Takahashi, R., Ujiro, S., Tange, S., ... & Imoto, I. (2020). Claudin-6 is a single prognostic marker and functions as a tumor-promoting gene in a subgroup of intestinal type gastric cancer. Gastric Cancer, 23(3), 403-417.

Lewis, J. B., Bodine, J. S., Gassman, J. R., Muñoz, S. A., Milner, D. C., Dunaway, T. M., ... & Reynolds, P. R. (2018). Transgenic up-regulation of Claudin-6 decreases fine diesel particulate matter (DPM)-induced pulmonary inflammation. Environmental Science and Pollution Research, 25(18), 18179-18188.

Lin, D., Guo, Y., Li, Y., Ruan, Y., Zhang, M., Jin, X., ... & Quan, C. (2017). Bioinformatic analysis reveals potential properties of human Claudin-6 regulation and functions. Oncology reports, 38(2), 875-885.

Bekki, H., Yamamoto, H., Takizawa, K., Iwasaki, T., Otsuka, H., Yamada, Y., ... & Oda, Y. (2017). Claudin 6 expression is useful to distinguish myxofibrosarcomas from other myxoid soft tissue tumors. Pathology-Research and Practice, 213(6), 674-679.

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For research use only. Not intended for any clinical use.

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