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Mouse Anti-CIT Recombinant Antibody (C7861) (CBMAB-C7861-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Horse, Cattle, Dog, Pig
Clone
C7861
Antibody Isotype
IgG2b, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 2036-2055 at the C-terminus of CRIK of mouse.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Horse, Cattle, Dog, Pig
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CIT
Introduction
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Entrez Gene ID
Human11113
Mouse12704
Rat83620
UniProt ID
HumanO14578
MouseP49025
RatE9PSL7
Alternative Names
Citron Rho-Interacting Serine/Threonine Kinase; Citron (Rho-Interacting, Serine/Threonine Kinase 21); Serine/Threonine-Protein Kinase 21; Serine/Threonine Kinase 21; STK21; CRIK; Citron Rho-Interacting Kinase;
Function
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Biological Process
Actomyosin structure organization Source: GO_Central
Generation of neurons Source: UniProtKB
Intracellular signal transduction Source: InterPro
Mitotic cell cycle Source: UniProtKB
Mitotic cytokinesis Source: UniProtKB
Negative regulation of hippo signaling Source: FlyBase
Neuron apoptotic process Source: UniProtKB
Peptidyl-threonine phosphorylation Source: GO_Central
Positive regulation of cytokinesis Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Microcephaly 17, primary, autosomal recessive (MCPH17):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH17 is a severe form characterized by lissencephaly, enlarged ventricles, agenesis of the corpus callosum, cerebellar hypoplasia, and brainstem hypoplasia. Patients manifest delayed psychomotor development, intellectual disability, spasticity, axial hypotonia, and dysmorphic features.
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For research use only. Not intended for any clinical use.

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