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Mouse Anti-CIT Recombinant Antibody (0462) (CBMAB-0462-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Horse, Cattle, Dog, Pig
Clone
0462
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1569-1597 at the C-terminus of CRIK of mouse.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Horse, Cattle, Dog, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CIT
Introduction
This gene encodes a serine/threonine-protein kinase that functions in cell division. Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Entrez Gene ID
11113
UniProt ID
O14578
Alternative Names
CITK; CRIK; STK21; MCPH17
Function
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
Biological Process
Actomyosin structure organization Source: GO_Central
Generation of neurons Source: UniProtKB
Intracellular signal transduction Source: InterPro
Mitotic cell cycle Source: UniProtKB
Mitotic cytokinesis Source: UniProtKB
Negative regulation of hippo signaling Source: FlyBase
Neuron apoptotic process Source: UniProtKB
Peptidyl-threonine phosphorylation Source: GO_Central
Positive regulation of cytokinesis Source: UniProtKB
Cellular Location
Cytoplasm
Involvement in disease
Microcephaly 17, primary, autosomal recessive (MCPH17):
A form of microcephaly, a disease defined as a head circumference more than 3 standard deviations below the age, sex and ethnically matched mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. MCPH17 is a severe form characterized by lissencephaly, enlarged ventricles, agenesis of the corpus callosum, cerebellar hypoplasia, and brainstem hypoplasia. Patients manifest delayed psychomotor development, intellectual disability, spasticity, axial hypotonia, and dysmorphic features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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