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Mouse Anti-CHST4 Recombinant Antibody (C7246) (CBMAB-C7246-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C7246
Antibody Isotype
IgG1
Application
IP, Neutralization

Basic Information

Immunogen
Recombinant human Sulfotransferase 4/CHST4 His29-His386.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IP8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Carbohydrate Sulfotransferase 4
Introduction
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Entrez Gene ID
10164
UniProt ID
Q8NCG5
Alternative Names
Carbohydrate Sulfotransferase 4; Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 3; High Endothelial Cells N-Acetylglucosamine 6-O-Sulfotransferase; Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 4; N-Acetylglucosamine 6-O-
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.
Biological Process
Carbohydrate metabolic process Source: UniProtKB-KW
Cell adhesion Source: ProtInc
Cell-cell signaling Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
N-acetylglucosamine metabolic process Source: UniProtKB
O-glycan processing Source: Reactome
Protein sulfation Source: GO_Central
Sulfur compound metabolic process Source: UniProtKB
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-7
Helical: 8-28
Lumenal: 29-386
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For research use only. Not intended for any clinical use.

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