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Mouse Anti-CHST4 Recombinant Antibody (CBXC-0426) (CBMAB-C3185-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0426
Antibody Isotype
IgG2b, κ
Application
ELISA

Basic Information

Immunogen
CHST4 (221 a.a. ~ 320 a.a) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carbohydrate Sulfotransferase 4
Introduction
This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein.
Entrez Gene ID
10164
UniProt ID
Q8NCG5
Alternative Names
Carbohydrate Sulfotransferase 4; Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 3; High Endothelial Cells N-Acetylglucosamine 6-O-Sulfotransferase; Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 4; N-Acetylglucosamine 6-O-Sulfotransferase 2; L-Selectin Ligand Sulfotransferase; HEC-GlcNAc6ST; GlcNAc6ST-2; Gn6st-2; GST-3;
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within mucin-associated glycans that ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X on receptors SPN/CD43, GLYCAM1 and MADCAM1. Also involved in biosynthesis of SELL ligand recognized by MECA-79 antibody. Plays a central role in lymphocyte trafficking during chronic inflammation. Has a catalytic preference for core 2-branched mucin-type O-glycans. Can use GlcNAcbeta1-6[Galbeta1-3]GalNAc-pNP (core 2), GlcNAcbeta1-6ManOMe and GlcNAcbeta1-2Man oligosaccharide structures as acceptors. Has also activity toward core 3 of GlcNAcbeta1-3GalNAc-pNP. Its substrate specificity may be influenced by its subcellular location.
Biological Process
Carbohydrate metabolic process Source: UniProtKB-KW
Cell adhesion Source: ProtInc
Cell-cell signaling Source: ProtInc
Immune response Source: ProtInc
Inflammatory response Source: UniProtKB-KW
N-acetylglucosamine metabolic process Source: UniProtKB
O-glycan processing Source: Reactome
Protein sulfation Source: GO_Central
Sulfur compound metabolic process Source: UniProtKB
Cellular Location
Golgi apparatus membrane
Topology
Cytoplasmic: 1-7
Helical: 8-28
Lumenal: 29-386
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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