Rabbit Anti-CHRD Recombinant Antibody (CBFYC-1849) (CBMAB-C1913-FY)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

CBFYC-1849

Antibody Isotype

IgG

Application

IHC-P

Basic Information

Immunogen

A synthetic peptide corresponding to the center region of the Human chordin.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IHC-P	1:100-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Chordin

Introduction

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined.

Entrez Gene ID

8646

UniProt ID

Q9H2X0

Alternative Names

Chordin

Function

Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity).

Biological Process

BMP signaling pathway involved in spinal cord dorsal/ventral patterning Source: BHF-UCL
Floor plate development Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: BHF-UCL
Negative regulation of cell migration Source: BHF-UCL
Negative regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of cell adhesion Source: BHF-UCL
Positive regulation of mesenchymal cell proliferation Source: BHF-UCL
Skeletal system development Source: UniProtKB

Cellular Location

Secreted

PTM

Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development.

More Infomation

References

Kumar, V., Goutam, R. S., Umair, Z., Park, S., Lee, U., & Kim, J. (2021). Foxd4l1. 1 Negatively Regulates Chordin Transcription in Neuroectoderm of Xenopus Gastrula. Cells, 10(10), 2779.

Kumar, V., Umair, Z., Kumar, S., Lee, U., & Kim, J. (2021). Smad2 and Smad3 differentially modulate chordin transcription via direct binding on the distal elements in gastrula Xenopus embryos. Biochemical and Biophysical Research Communications, 559, 168-175.

Wang, Y. W., Wu, C. H., Lin, T. Y., & Luo, C. W. (2021). Expression profiling of ovarian BMP antagonists reveals the potential interaction between TWSG1 and the chordin subfamily in the ovary. Molecular and Cellular Endocrinology, 538, 111457.

Abbas-Tehrani, H. (2021). The BMP antagonist CHORDIN as a regulator of osteoclast formation and function: an in vitro study.

Glister, C., Regan, S. L., Samir, M., & Knight, P. G. (2019). Gremlin, noggin, chordin and follistatin differentially modulate BMP-induced suppression of androgen secretion by bovine ovarian theca cells. Journal of molecular endocrinology, 62(1), 15-25.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rat Anti-CHRD Recombinant Antibody (C10980)

Rat Anti-CHRD Recombinant Antibody (1365)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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