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Rat Anti-Chil3 Recombinant Antibody (CBXC-1676) (CBMAB-C3233-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1676
Antibody Isotype
IgG2b, λ
Application
IP, WB, IF, IHC-P

Basic Information

Immunogen
Synthetic peptide corresponding to residues surrounding AA 280 of mouse Chil3.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2b, λ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:500
WB1:100-1:250
IHC-P1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chitinase-like 3
Introduction
The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy.
Entrez Gene ID
12655
UniProt ID
O35744
Alternative Names
Ym1; ECF-L; Chi3l3; AI505981
Function
Lectin that binds saccharides with a free amino group, such as glucosamine or galactosamine. Binding to oligomeric saccharides is much stronger than binding to mono- or disaccharides. Also binds chitin and heparin. Has weak hexosaminidase activity but no chitinase activity. Has chemotactic activity for T-lymphocytes, bone marrow cells and eosinophils. May play a role in inflammation and allergy.
Biological Process
Chitin catabolic process Source: GO_Central
Inflammatory response Source: MGI
Polysaccharide catabolic process Source: UniProtKB-KW
Cellular Location
Rough endoplasmic reticulum lumen; Secreted; Nucleus envelope; Cytoplasm; Cytoplasmic granule. Predominantly localizes to the lumen of rough endoplasmic reticulum (rER) and nuclear envelope in alveolar macrophages. Localizes to the dilated lumen of rER in immature neutrophils in spleen and in cytoplasmic granules in peritoneal neutrophils. Detected in needle-shaped crystals present in the cytoplasm of bone marrow macrophages.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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