Rabbit Anti-CEND1 Recombinant Antibody (BA0246) (CBMAB-0220CQ)

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Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse, Rat

Clone

BA0246

Antibody Isotype

IgG

Application

WB, IHC-P, IF

Basic Information

Immunogen

Recombinant protein within Human CEND1 aa 31-140.

Host Species

Rabbit

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000-1:5,000
IF(ICC)	1:50-1:200
IHC-P	1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

TBS, pH 7.4, 0.05% BSA, 40% glycerol

Preservative

0.05% sodium azide

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Cell Cycle Exit And Neuronal Differentiation 1

Introduction

The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. By genomic sequence analysis and by FISH, Gaitanou et al. (2001) mapped the BM88 gene to chromosome 11p15.5. By searching an EST database for sequences similar to porcine Bm88. The deduced 149-amino acid BM88 protein has a calculated molecular mass of about 15 kD.

Entrez Gene ID

Human	51286
Mouse	57754
Rat	361675

UniProt ID

Human	Q8N111
Mouse	Q9JKC6
Rat	Q5FVI4

Alternative Names

Cell Cycle Exit And Neuronal Differentiation 1; BM88 Antigen; BM88

Function

Involved in neuronal differentiation.

Biological Process

Adult walking behavior Source: Ensembl
Cerebellar granular layer maturation Source: GO_Central
Cerebellar Purkinje cell differentiation Source: GO_Central
Negative regulation of cerebellar granule cell precursor proliferation Source: Ensembl
Radial glia guided migration of cerebellar granule cell Source: GO_Central

Cellular Location

Membrane

Topology

Cytoplasmic: 1-125
Helical: 126-146
Extracellular: 147-149

More Infomation

References

Wang, R., Yang, D. X., Liu, Y. L., Ding, J., Guo, Y., Ding, W. H., ... & Yuan, F. (2022). Cell cycle exit and neuronal differentiation 1-engineered embryonic neural stem cells enhance neuronal differentiation and neurobehavioral recovery after experimental traumatic brain injury. Neural Regeneration Research, 17(1), 130.

Zhou, P., Qi, Y., Fang, X., Yang, M., Zheng, S., Liao, C., ... & Hu, H. (2021). Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m6A-methylation of Npdc1 and Cend1. Iscience, 102645.

Aravantinou-Fatorou, K., Vejdani, S., & Thomaidou, D. (2021). Cend1 and Neurog2 efficiently reprogram human cortical astrocytes to neural precursor cells and induced-neurons. International Journal of Developmental Biology.

Gaitanou, M., Segklia, K., & Matsas, R. (2019). CEND1, a story with many tales: from regulation of cell cycle progression/exit of neural stem cells to brain structure and function. Stem cells international, 2019.

Tzortzopoulos, A., Thomaidou, D., Gaitanou, M., Matsas, R., & Skoulakis, E. (2019). Expression of Mammalian BM88/CEND1 in Drosophila Affects Nervous System Development by Interfering with Precursor Cell Formation. Neuroscience bulletin, 35(6), 979-995.

Segklia, K., Stamatakis, A., Stylianopoulou, F., Lavdas, A. A., & Matsas, R. (2019). Increased anxiety-related behavior, impaired cognitive function and cellular alterations in the brain of Cend1-deficient mice. Frontiers in cellular neuroscience, 12, 497.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CEND1 Recombinant Antibody (CBWJC-2476)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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