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Rabbit Anti-CELA3B Recombinant Antibody (C4184) (CBMAB-C4184-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
C4184
Antibody Isotype
IgG
Application
IHC

Basic Information

Immunogen
Recombinant human Elastase protein fragment (aa 82-238).
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC1-2 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA
Preservative
0.05% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chymotrypsin Like Elastase Family Member 3B
Introduction
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
Entrez Gene ID
23436
UniProt ID
P08861
Alternative Names
Chymotrypsin Like Elastase Family Member 3B; Cholesterol-Binding Pancreatic Protease; Pancreatic Endopeptidase E; Elastase 3B, Pancreatic; Elastase IIIB; Proteinase E; Elastase-3B; Protease E; ELA3B;
Function
Efficient protease with alanine specificity but only little elastolytic activity.
Biological Process
Proteolysis Source: GO_Central
Cellular Location
Extracellular space
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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