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Mouse Anti-CEBPE Recombinant Antibody (CBYY-C1861) (CBMAB-C3299-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1861
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to an internal region of C/EBP ε of human.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CEBPE
Entrez Gene ID
1053
UniProt ID
Q15744
Alternative Names
Centrin 1; Centrin, EF-Hand Protein, 1; CETN; CEN1; Testicular Tissue Protein Li 37; Calcium Binding Protein;
Function
Transcriptional activator (PubMed:26019275).
C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Required for the promyelocyte-myelocyte transition in myeloid differentiation (PubMed:10359588).
Biological Process
Cellular response to lipopolysaccharide Source: Ensembl
Defense response Source: ProtInc
Defense response to bacterium Source: Ensembl
Granulocyte differentiation Source: UniProtKB
Macrophage differentiation Source: Ensembl
Myeloid cell differentiation Source: GO_Central
Phagocytosis Source: Ensembl
Positive regulation of gene expression Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Specific granule deficiency 1 (SGD1): An autosomal recessive disorder characterized by recurrent pyogenic infections, defective neutrophil chemotaxis and bactericidal activity, and lack of neutrophil secondary granule proteins. Neutrophils of affected individuals lack lactoferrin and show abnormal nuclear segmentation, bilobed nuclei, low alkaline phosphatase, and increased number of neutrophil mitochondria and ribosomes.
PTM
Phosphorylated.
More Infomation

Stankiewicz, M. J., Du, J., Martinico, D., & Ackerman, S. J. (2021). CCAAT/Enhancer-Binding Protein ε27 Antagonism of GATA-1 Transcriptional Activity in the Eosinophil Is Mediated by a Unique N-Terminal Repression Domain, Is Independent of Sumoylation and Does Not Require DNA Binding. International Journal of Molecular Sciences, 22(23), 12689.

Göös, H., Fogarty, C. L., Sahu, B., Plagnol, V., Rajamäki, K., Nurmi, K., ... & Seppänen, M. R. (2019). Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. Journal of Allergy and Clinical Immunology, 144(5), 1364-1376.

Shyamsunder, P., Shanmugasundaram, M., Mayakonda, A., Dakle, P., Teoh, W. W., Han, L., ... & Koeffler, H. P. (2019). Identification of a novel enhancer of CEBPE essential for granulocytic differentiation. Blood, The Journal of the American Society of Hematology, 133(23), 2507-2517.

Studd, J. B., Yang, M., Li, Z., Vijayakrishnan, J., Lu, Y., Yeoh, A. E. J., ... & Houlston, R. S. (2019). Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11. 2 is mediated by a CEBPE promoter polymorphism. Leukemia, 33(1), 1-14.

Serwas, N. K., Huemer, J., Dieckmann, R., Mejstrikova, E., Garncarz, W., Litzman, J., ... & Boztug, K. (2018). CEBPE-mutant specific granule deficiency correlates with aberrant granule organization and substantial proteome alterations in neutrophils. Frontiers in immunology, 9, 588.

Burmeister, T. (2017). CEBPE (CCAAT/enhancer binding protein epsilon). Atlas of Genetics and Cytogenetics in Oncology and Haematology.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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