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Rabbit Anti-CEBPB Recombinant Antibody (EG635) (CBMAB-EN767-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG635
Antibody Isotype
IgG
Application
FC, IP, IF, WB

Basic Information

Immunogen
The antibody was produced against synthesized phosphopeptide derived from human C/EBP-β around the phosphorylation site of threonine 235/188 (P-G-TP-P-S).
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IP1:50
FC1:50
WB1:500-1:2,000
IF(ICC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol, 0.4-0.5mg/ml BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCAAT/Enhancer Binding Protein Beta
Introduction
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]
Entrez Gene ID
Human1051
Mouse12608
Rat24253
UniProt ID
HumanP17676
MouseP28033
RatP21272
Alternative Names
CCAAT/Enhancer Binding Protein Beta; CCAAT/Enhancer Binding Protein (C/EBP), Beta; Interleukin 6-Dependent DNA-Binding Protein; Nuclear Factor Of Interleukin 6; Transcription Factor 5; Nuclear Factor NF-IL6; TCF5; Liver-Enriched Transcriptional Activator Protein; CCAAT/Enhancer-Binding Protein Beta; Liver-Enriched Inhibitory Protein;
More Infomation

Zhang, X., Wu, Z., Bu, M., Hu, R., Zhang, X., Li, W., & Chen, L. (2021). The CCAAT/Enhancer Binding Protein Beta (cebpb) is essential for the development of enveloping layer (EVL) in zebrafish. Aquaculture and Fisheries.

Lala‐Tabbert, N., AlSudais, H., Marchildon, F., Fu, D., & Wiper‐Bergeron, N. (2021). CCAAT/enhancer‐binding protein beta promotes muscle stem cell quiescence through regulation of quiescence‐associated genes. STEM CELLS, 39(3), 345-357.

Lee, G., Jang, E., & Youn, J. (2020). CCAAT/enhancer binding protein β Induces post-switched B cells to produce Blimp1 and differentiate into plasma cells. Immune Network, 20(5).

Merrett, J. E., Bo, T., Psaltis, P. J., & Proud, C. G. (2020). Identification of DNA response elements regulating expression of CCAAT/enhancer-binding protein (C/EBP) β and δ and MAP kinase-interacting kinases during early adipogenesis. Adipocyte, 9(1), 427-442.

Yang, H., Kang, M. J., Hur, G., Lee, T. K., Park, I. S., Seo, S. G., ... & Lee, K. W. (2020). Sulforaphene suppresses adipocyte differentiation via induction of post-translational degradation of CCAAT/Enhancer binding protein beta (C/EBPβ). Nutrients, 12(3), 758.

AlSudais, H., & Wiper-Bergeron, N. (2019). Contaminating reactivity of a monoclonal CCAAT/Enhancer Binding Protein β antibody in differentiating myoblasts. BMC research notes, 12(1), 1-6.

AlSudais, H., Lala-Tabbert, N., & Wiper-Bergeron, N. (2018). CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3. Scientific reports, 8(1), 1-10.

Simpson-Abelson, M. R., Hernandez-Mir, G., Childs, E. E., Cruz, J. A., Poholek, A. C., Chattopadhyay, A., ... & McGeachy, M. J. (2017). CCAAT/Enhancer-binding protein β promotes pathogenesis of EAE. Cytokine, 92, 24-32.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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