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Rabbit Anti-CDX1 Recombinant Antibody (CBXC-1549) (CBMAB-C5070-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXC-1549
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Immunogen
A synthesized peptide derived from human Cdx1.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:50-1:200
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol, 0.4-0.5mg/ml BSA
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Caudal Type Homeobox 1
Introduction
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity.
Entrez Gene ID
1044
UniProt ID
P47902
Alternative Names
Caudal Type Homeobox 1; Caudal Type Homeo Box Transcription Factor 1; Caudal-Type Homeobox Protein 1;
Function
Plays a role in transcriptional regulation (PubMed:24623306).
Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells (PubMed:24623306).
Binds to the PRKD1 promoter in colorectal cancer (CRC) cells (PubMed:24623306).
Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA (PubMed:28473536).
Biological Process
Animal organ morphogenesis Source: GO_Central
Anterior/posterior axis specification Source: GO_Central
Bone morphogenesis Source: Ensembl
Cell differentiation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of somitogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
More Infomation

Lei, D., Sun, H., & Zhang, B. (2021). MiR-24 Promotes Cell Growth in Human Glioma by CDX1/PI3K/Akt Signaling Pathway. Cancer Biotherapy & Radiopharmaceuticals, 36(7), 588-599.

Kim, K., Noh, S., Cheong, J. H., & Kim, H. (2021). CDX-1/CDX-2 Expression Is a Favorable Prognostic Factor in Epstein-Barr Virus-Negative, Mismatch Repair-Proficient Advanced Gastric Cancers. Gut and Liver, 15(5), 694.

Ma, L., Cao, Y., Hu, J. J., & Chu, M. L. (2020). Casein kinase 2 interacting protein 1 positively regulates caudal-related homeobox 1 in intestinal-type gastric cancer. Chinese medical journal, 133(2), 154.

Samadani, A. A., Nikbakhsh, N., Taheri, H., Shafaee, S., Fattahi, S., Langroudi, M. P., ... & Akhavan-Niaki, H. (2019). CDX1/2 and KLF5 expression and epigenetic modulation of sonic hedgehog signaling in gastric adenocarcinoma. Pathology & Oncology Research, 25(3), 1215-1222.

Nakayama, C., Yamamichi, N., Tomida, S., Takahashi, Y., Kageyama‐Yahara, N., Sakurai, K., ... & Koike, K. (2018). Transduced caudal‐type homeobox (CDX) 2/CDX 1 can induce growth inhibition on CDX‐deficient gastric cancer by rapid intestinal differentiation. Cancer science, 109(12), 3853-3864.

Zheng, R., Lin, S., Guan, L., Yuan, H., Liu, K., Liu, C., ... & Zhang, R. (2018). Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis. Biochemical and biophysical research communications, 498(4), 1002-1008.

Kiani, S., Akhavan-Niaki, H., Fattahi, S., Kavoosian, S., Jelodar, N. B., Bagheri, N., & Zarrini, H. N. (2018). Purified sulforaphane from broccoli (Brassica oleracea var. italica) leads to alterations of CDX1 and CDX2 expression and changes in miR-9 and miR-326 levels in human gastric cancer cells. Gene, 678, 115-123.

Yang, L., Li, C., Liang, F., Fan, Y., & Zhang, S. (2017). MiRNA-155 promotes proliferation by targeting caudal-type homeobox 1 (CDX1) in glioma cells. Biomedicine & Pharmacotherapy, 95, 1759-1764.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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