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Mouse Anti-CDON Recombinant Antibody (CBXC-0350) (CBMAB-C3210-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-0350
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 31-174 mapping near the N-terminus of CDO of mouse.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:500-1:5,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Adhesion Associated, Oncogene Regulated
Introduction
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Entrez Gene ID
50937
UniProt ID
Q4KMG0
Alternative Names
Cell Adhesion Associated, Oncogene Regulated; Cell Adhesion Molecule-Related/Down-Regulated By Oncogenes; CDO; Surface Glycoprotein, Ig Superfamily Member; Cdon Homolog (Mouse); Cdon Homolog; CDON1; HPE11; ORCAM;
Function
Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells (By similarity).
Biological Process
Anterior/posterior pattern specification Source: Ensembl
Cell adhesion Source: UniProtKB
Cell fate specification Source: Ensembl
Cerebral cortex development Source: Ensembl
Embryonic body morphogenesis Source: Ensembl
Embryonic retina morphogenesis in camera-type eye Source: Ensembl
Lens development in camera-type eye Source: Ensembl
Myoblast fusion Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Positive regulation of muscle cell differentiation Source: Reactome
Positive regulation of myoblast differentiation Source: InterPro
Positive regulation of neural precursor cell proliferation Source: Ensembl
Positive regulation of neuron differentiation Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Positive regulation of skeletal muscle tissue development Source: Ensembl
Positive regulation of small GTPase mediated signal transduction Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Regulation of protein binding Source: Ensembl
Skeletal muscle satellite cell differentiation Source: Ensembl
Smoothened signaling pathway Source: Ensembl
Cellular Location
Cell membrane
Involvement in disease
Holoprosencephaly 11 (HPE11): A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability.
Topology
Extracellular: 26-963
Helical: 964-984
Cytoplasmic: 985-1287
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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