Mouse Anti-CDK3 Recombinant Antibody (3C12) (CBMAB-C5794-LY)

Name: Mouse Anti-CDK3 Recombinant Antibody (3C12)
SKU: CBMAB-C5794-LY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

3C12

Antibody Isotype

IgG1, κ

Application

ELISA, WB

Basic Information

Immunogen

CDK3 (206 a.a. ~ 305 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

cyclin-dependent kinase 3

Introduction

CDK3 (Cyclin Dependent Kinase 3) is a Protein Coding gene. Among its related pathways are Cell Cycle Control of Chromosomal Replication and GADD45 Pathway. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK2.

Entrez Gene ID

1018

UniProt ID

Q00526

Alternative Names

Cyclin Dependent Kinase 3; EC 2.7.11.22; Cell Division Protein Kinase 3; EC 2.7.11; CDKN3;

Function

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner.

Biological Process

Cell division Source: UniProtKB-KW
Cell population proliferation Source: UniProtKB
Cellular response to DNA damage stimulus Source: MGI
G0 to G1 transition Source: UniProtKB
G1/S transition of mitotic cell cycle Source: UniProtKB
Protein phosphorylation Source: GO_Central

Cellular Location

Nucleus

More Infomation

References

Liu, Z. H., Yang, S. Z., Li, W. Y., Dong, S. Y., Zhou, S. Y., & Xu, S. (2021). CircRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene. Aging (Albany NY), 13(8), 12179.

Bailey, K., & Meredith, H. (2019). Effect of Mine Runoff Metals on the Cyclin-Dependent Kinase 3 (CDK3) Gene of Tetrahymena thermophila.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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