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Human Anti-CDH6 Recombinant Antibody (CBYY-C0220) (CBMAB-C0634-YY)


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Summary

Host Animal
Human
Specificity
Human
Clone
CBYY-C0220
Antibody Isotype
IgG1
Application
FC, ELISA

Basic Information

Immunogen
CDH6.
Host Species
Human
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
8% sucrose, 0.01% Tween80
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cadherin 6
Entrez Gene ID
1004
UniProt ID
P55285
Alternative Names
Calcium/Calmodulin Dependent Protein Kinase II Gamma; Calcium/Calmodulin-Dependent Protein Kinase (CaM Kinase) II Gamma; CaMK-II Subunit Gamma; EC 2.7.11.17; CAMK-II; CAMKG;
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Biological Process
Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell adhesion Source: ProtInc
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central
Notch signaling pathway Source: Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 54-615
Helical: 616-636
Cytoplasmic: 637-790
More Infomation

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). High expression of oncogene cadherin-6 correlates with tumor progression and a poor prognosis in gastric cancer. Cancer cell international, 21(1), 1-9.

Gugnoni, M., Manicardi, V., Torricelli, F., Sauta, E., Bellazzi, R., Manzotti, G., ... & Ciarrocchi, A. (2021). Linc00941 is a novel transforming growth factor β target that primes papillary thyroid cancer metastatic behavior by regulating the expression of cadherin 6. Thyroid, 31(2), 247-263.

Bouck, E. G., de la Fuente, M., Zunica, E. R., Li, W., Mumaw, M. M., & Nieman, M. T. (2021). Murine cadherin‐6 mediates thrombosis in vivo in a platelet‐independent manner. Research and Practice in Thrombosis and Haemostasis, 5(1), 125-131.

Zhao, Z., Li, S., Li, S., Wang, J., Lin, H., & Fu, W. (2021). Overexpression of a novel oncogene Cadherin 6 correlates with tumor progression and poor prognosis in gastric cancer.

Ma, C., Zhao, J. Z., Lin, R. T., Zhou, L., Chen, Y. N., Yu, L. J., ... & Zhang, T. (2018). Combined overexpression of cadherin 6, cadherin 11 and cluster of differentiation 44 is associated with lymph node metastasis and poor prognosis in oral squamous cell carcinoma. Oncology letters, 15(6), 9498-9506.

Gugnoni, M., Sancisi, V., Gandolfi, G., Manzotti, G., Ragazzi, M., Giordano, D., ... & Ciarrocchi, A. (2017). Cadherin-6 promotes EMT and cancer metastasis by restraining autophagy. Oncogene, 36(5), 667-677.

Zuo, L. L., Zhang, J., Liu, L. Z., Zhou, Q., Du, S. J., Xin, S. Y., ... & Lu, J. H. (2017). Cadherin 6 is activated by Epstein–Barr virus LMP1 to mediate EMT and metastasis as an interplay node of multiple pathways in nasopharyngeal carcinoma. Oncogenesis, 6(12), 1-16.

Bialucha, C. U., Collins, S. D., Li, X., Saxena, P., Zhang, X., Dürr, C., ... & Lees, E. (2017). Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers. Cancer discovery, 7(9), 1030-1045.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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