Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Human Anti-CDCP1 Recombinant Antibody (CBXC-1088) (CBMAB-C5745-CQ)


See all CDCP1 antibodies
Online Inquiry

Summary

Host Animal
Human
Specificity
Human
Clone
CBXC-1088
Antibody Isotype
IgG1
Application
FC, ELISA

Basic Information

Immunogen
CDCP1/CD318.
Host Species
Human
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
8% sucrose, 0.01% Tween80
Preservative
None
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CUB Domain Containing Protein 1
Introduction
CDCP1 (CUB Domain Containing Protein 1) is a Protein Coding gene. Diseases associated with CDCP1 include Colorectal Cancer. Among its related pathways are Wnt / Hedgehog / Notch and NF-kappaB Signaling.
Entrez Gene ID
64866
UniProt ID
Q9H5V8
Alternative Names
CUB Domain Containing Protein 1; Subtractive Immunization M Plus HEp3-Associated 135 KDa Protein; Transmembrane And Associated With Src Kinases; Membrane Glycoprotein Gp140; SIMA135; TRASK; CUB Domain-Containing Protein 1; CD318 Antigen; CD318;
Function
May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.
Biological Process
Isoform 1: Cell membrane. Shedding may also lead to a soluble peptide.
Isoform 3: Secreted
Topology
Extracellular: 30-667
Helical: 668-688
Cytoplasmic: 689-836
PTM
Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5.
N-glycosylated.
A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease.
More Infomation

Wang, M., Liu, D., Murthy, V., Nguyen, T. T., Lim, D. Y., Huang, R., ... & Pereira, N. (2021, May). ROLE AND FUNCTIONAL CHARACTERIZATION OF CUB-DOMAIN CONTAINING PROTEIN 1 (CDCP1) IN DILATED CARDIOMYOPATHY. In Journal of the American College of Cardiology (Vol. 77, No. 18, pp. 537-537). STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA: ELSEVIER SCIENCE INC.

Khan, T., Kryza, T., Lyons, N. J., He, Y., & Hooper, J. D. (2021). The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention. Cancer Research, 81(9), 2259-2269.

Mamoor, S. (2021). Over-expression of CUB domain containing protein 1 in human endometrial cancer.

Moroz, A., Wang, Y. H., Sharib, J. M., Wei, J., Zhao, N., Huang, Y., ... & Evans, M. J. (2020). Theranostic targeting of CUB domain containing protein 1 (CDCP1) in pancreatic cancer. Clinical Cancer Research, 26(14), 3608-3615.

Huang, L., Chen, Y., Lai, S., Guan, H., Hu, X., Liu, J., ... & Zhou, J. (2020). CUB Domain-Containing Protein-1 Promotes Proliferation, Migration and Invasion in Cervical Cancer Cells. Cancer management and research, 12, 3759.

Nelson, L. J., Wright, H. J., Dinh, N. B., Nguyen, K. D., Razorenova, O. V., & Heinemann, F. S. (2020). Src Kinase Is Biphosphorylated at Y416/Y527 and Activates the CUB-Domain Containing Protein 1/Protein Kinase C δ Pathway in a Subset of Triple-Negative Breast Cancers. The American journal of pathology, 190(2), 484-502.

Predes, D., Cruz, J. V. R., Abreu, J. G., & Mendes, F. A. (2019). CUB domain-containing protein 1 (CDCP1) binds transforming growth factor beta family members and increase TGF-β1 signaling pathway. Experimental cell research, 383(1), 111499.

Kajiwara, K., Sugihara, A., Aoki, K., Okuzaki, D., Matsumoto, K., & Okada, M. (2019). CUB domain-containing protein 1 controls HGF responses by integrating Src and Met–STAT3 signaling. bioRxiv, 789339.

Kuhara, K., Tokuda, K., Kitagawa, T., Baron, B., Tokunaga, M., Harada, K., ... & Kuramitsu, Y. (2018). CUB domain-containing protein 1 (CDCP1) is down-regulated by Active Hexose-Correlated Compound in human pancreatic cancer cells. Anticancer research, 38(11), 6107-6111.

Noskovičová, N., Heinzelmann, K., Burgstaller, G., Behr, J., & Eickelberg, O. (2018). Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. American Journal of Physiology-Lung Cellular and Molecular Physiology, 314(5), L695-L707.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Human Anti-CDCP1 Recombinant Antibody (CBXC-1088)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry