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Mouse Anti-CD48 Recombinant Antibody (CBYY-C0124) (CBMAB-C0465-YY)


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Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBYY-C0124
Antibody Isotype
IgG2a
Application
IF, IP, WB, FC

Basic Information

Immunogen
T blasts from a mixed lymphocyte reaction of rat origin.
Host Species
Mouse
Specificity
Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD48 Molecule
Entrez Gene ID
Human4179
Monkey714082
UniProt ID
HumanP15529
MonkeyF7DTG0
Function
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
Biological Process
Defense response Source: ProtInc
Leukocyte migration Source: Reactome
Regulation of adaptive immune response Source: InterPro
Cellular Location
Cell membrane
More Infomation

Wang, Z., He, L., Li, W., Xu, C., Zhang, J., Wang, D., ... & Li, M. (2021). GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. Journal for immunotherapy of cancer, 9(9).

Ziblat, A., Iraolagoitia, X. L. R., Nuñez, S. Y., Torres, N. I., Secchiari, F., Sierra, J. M., ... & Zwirner, N. W. (2021). Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1. Frontiers in immunology, 12, 2143.

Wang, Z., Xie, C., Li, Y., Cai, J., Tang, J., Jian, J., ... & Lu, Y. (2020). Molecular characterization and expression of CD48 in Nile tilapia (Oreochromis niloticus) in response to different stimulus. Fish & shellfish immunology, 97, 515-522.

Martínez-Vicente, P., Farré, D., Engel, P., & Angulo, A. (2020). Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family. Viruses, 12(8), 813.

Wang, Z., Xiao, Y., Guan, W., Wang, M., Chen, J., Zhang, L., ... & Yu, L. (2020). Acute myeloid leukemia immune escape by epigenetic CD48 silencing. Clinical Science, 134(2), 261-271.

Zou, C., Zhu, C., Guan, G., Guo, Q., Liu, T., Shen, S., ... & Cheng, W. (2019). CD48 is a key molecule of immunomodulation affecting prognosis in glioma. OncoTargets and therapy, 12, 4181.

Pahima, H., Puzzovio, P. G., & Levi-Schaffer, F. (2019). 2B4 and CD48: A powerful couple of the immune system. Clinical Immunology, 204, 64-68.

Martinez-Vicente, P., Farré, D., Sánchez, C., Alcamí, A., Engel, P., & Angulo, A. (2019). Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor. PLoS pathogens, 15(4), e1007658.

Huang, C. H., Liao, Y. J., Chiou, T. J., Huang, H. T., Lin, Y. H., & Twu, Y. C. (2019). TGF-β regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression. Immunobiology, 224(5), 649-658.

Liu, R., Wu, C., Li, L., Chi, F., Zhang, T., Xu, Y., ... & Wang, L. (2019). CD48 and α7 nicotinic acetylcholine receptor synergistically regulate fimH-mediated Escherichia coli K1 penetration and neutrophil transmigration across human brain microvascular endothelial cells. The Journal of infectious diseases, 219(3), 470-479.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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