Mouse Anti-CD37 Recombinant Antibody (CBFYC-1243) (CBMAB-C1301-FY)

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Summary

Host Animal

Mouse

Specificity

Human

Clone

CBFYC-1243

Antibody Isotype

IgG1, κ

Application

WB, IF, IP, FC

Basic Information

Immunogen

EBV-transformed B-cell line.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

CD37 Molecule

Introduction

CD37 (CD37 Molecule) is a Protein Coding gene. Among its related pathways are Hematopoietic cell lineage. An important paralog of this gene is CD82.

Entrez Gene ID

951

UniProt ID

P11049

Cellular Location

Membrane

Topology

Cytoplasmic: 1-17
Helical: 18-38
Extracellular: 39-59
Helical: 60-74
Cytoplasmic: 75-85
Helical: 86-111
Extracellular: 112-241
Helical: 242-266
Cytoplasmic: 267-281

More Infomation

References

Okuno, S., Adachi, Y., Terakura, S., Julamanee, J., Sakai, T., Umemura, K., ... & Kiyoi, H. (2021). Spacer Length Modification Facilitates Discrimination between Normal and Neoplastic Cells and Provides Clinically Relevant CD37 CAR T Cells. The Journal of Immunology.

van der Horst, H. J., Oostindie, S. C., Cillessen, S. A., Gelderloos, A. T., Overdijk, M. B., Nijhof, I. S., ... & Mutis, T. (2021). Potent preclinical efficacy of DuoHexaBody-CD37 in B-cell malignancies. Hemasphere, 5(1).

Yan, X., Zhou, Q., Zhu, H., Liu, W., Xu, H., Yin, W., ... & Ren, C. (2021). The clinical features, prognostic significance, and immune heterogeneity of CD37 in diffuse gliomas. Iscience, 24(11), 103249.

Oostindie, S. C., van der Horst, H. J., Kil, L. P., Strumane, K., Overdijk, M. B., van den Brink, E. N., ... & Breij, E. C. (2020). DuoHexaBody-CD37®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies. Blood cancer journal, 10(3), 1-13.

Bobrowicz, M., Kubacz, M., Slusarczyk, A., & Winiarska, M. (2020). CD37 in B cell derived tumors—more than just a docking point for monoclonal antibodies. International Journal of Molecular Sciences, 21(24), 9531.

Zhang, Q., Han, Q., Zi, J., Song, C., & Ge, Z. (2020). CD37 high expression as a potential biomarker and association with poor outcome in acute myeloid leukemia. Bioscience reports, 40(5), BSR20200008.

Malenge, M. M. (2020). Combination of anti-CD37 radioimmunotherapy with anti-CD20 immunotherapy and small molecule inhibitors to improve therapy of non-Hodgkin lymphoma.

Oostindie, S. C., Van Der Horst, H. J., Lindorfer, M. A., Cook, E. M., Tupitza, J. C., Zent, C. S., ... & Taylor, R. P. (2019). CD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering. haematologica, 104(9), 1841.

Payandeh, Z., Noori, E., Khalesi, B., Mard-Soltani, M., Abdolalizadeh, J., & Khalili, S. (2018). Anti-CD37 targeted immunotherapy of B-Cell malignancies. Biotechnology letters, 40(11), 1459-1466.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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