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Mouse Anti-CD1A Recombinant Antibody (EC105) (V2LY-0624-LY105)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EC105
Antibody Isotype
IgG
Application
IHC-P, IF

Basic Information

Immunogen
Synthetic Peptide.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IHC-P1:100-1:300
IF(CC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
>95% by SDS Page
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD1a Molecule
Introduction
CD1A (CD1a Molecule) is a Protein Coding gene. Diseases associated with CD1A include Langerhans Cell Histiocytosis and Histiocytosis. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and endogenous lipid antigen binding. An important paralog of this gene is CD1B.
Entrez Gene ID
909
UniProt ID
P06126
Alternative Names
CD1a Molecule; T-Cell Surface Antigen T6/Leu-6; CD1A Antigen, A Polypeptide; HTa1 Thymocyte Antigen; CD1a Antigen; Epidermal Dendritic Cell Marker CD1a; Differentiation Antigen CD1-Alpha-3; T-Cell Surface Glycoprotein CD1a;
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Immune response Source: UniProtKB
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
Cellular Location
Endosome membrane; Cell membrane; Membrane raft. Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
Topology
Extracellular: 17-300
Helical: 301-321
Cytoplasmic: 322-327
More Infomation

de Jong, A., & Ogg, G. (2021). CD1a function in human skin disease. Molecular Immunology, 130, 14-19.

Gapin, L. (2021). CD1a autoreactivity: When size does matter.

Yoo, H. J., Kim, N. Y., & Kim, J. H. (2021). Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System. Molecules and Cells, 44(5), 310.

Cotton, R. N., Wegrecki, M., Cheng, T. Y., Chen, Y. L., Veerapen, N., Le Nours, J., ... & Moody, D. B. (2021). CD1a selectively captures endogenous cellular lipids that broadly block T cell response. Journal of Experimental Medicine, 218(7), e20202699.

Cotton, R. N., Cheng, T. Y., Wegrecki, M., Le Nours, J., Orgill, D. P., Pomahac, B., ... & Moody, D. B. (2021). Human skin is colonized by T cells that recognize CD1a independently of lipid. The Journal of clinical investigation, 131(1).

Nicolai, S., Wegrecki, M., Cheng, T. Y., Bourgeois, E. A., Cotton, R. N., Mayfield, J. A., ... & de Jong, A. (2020). Human T cell response to CD1a and contact dermatitis allergens in botanical extracts and commercial skin care products. Science immunology, 5(43).

Sánchez-Martínez, D., Baroni, M. L., Gutierrez-Agüera, F., Roca-Ho, H., Blanch-Lombarte, O., González-García, S., ... & Menéndez, P. (2019). Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia. Blood, The Journal of the American Society of Hematology, 133(21), 2291-2304.

Taheri, M., Danesh, H., Bizhani, F., Bahari, G., Naderi, M., & Hashemi, M. (2019). Association between genetic variants in CD1A and CD1D genes and pulmonary tuberculosis in an Iranian population. Biomedical reports, 10(4), 259-265.

Rahman, M. I., Jahan, I., Khalid, M. M., Jahan, I., Ahammad, R. U., Nahar, S., & Islam, Z. (2018). CD1A and CD1E gene polymorphisms are not associated with susceptibility to Guillain-Barré syndrome in the Bangladeshi population. Journal of neuroimmunology, 314, 8-12.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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