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Mouse Anti-CCNT2 Recombinant Antibody (2128C1a) (CBMAB-C0612-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2128C1a
Antibody Isotype
IgG1
Application
WB, IP

Basic Information

Immunogen
Recombinant protein corresponding to an internal region of cyclin T2a/b of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
cyclin T2
Introduction
CCNT2 (Cyclin T2) is a Protein Coding gene. Diseases associated with CCNT2 include Human Immunodeficiency Virus Type 1. Among its related pathways are Formation of HIV elongation complex in the absence of HIV Tat and Gene Expression. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNT1.
Entrez Gene ID
905
UniProt ID
O60583
Alternative Names
Cyclin T2; CYCT2; Subunit Of Positive Elongation Transcription Factor B; SDS-Stable Vimentin-Bound DNA Fragment HEF42VIM22; Cyclin T2a; Cyclin T2b; Cyclin-T2;
Function
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843).
The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533).
Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity).
In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689).
Involved in early embryo development (By similarity).
(Microbial infection) Promotes transcriptional activation of early and late herpes simplex virus 1/HHV-1 promoters.
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Early viral transcription Source: UniProtKB
Late viral transcription Source: UniProtKB
Positive regulation of DNA-templated transcription, elongation Source: GO_Central
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of muscle cell differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Skeletal muscle tissue development Source: Ensembl
snRNA transcription by RNA polymerase II Source: Reactome
Transcription by RNA polymerase II Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome
Cellular Location
Nucleus; Perinuclear region. Nucleus in differentiating cells.
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For research use only. Not intended for any clinical use.

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