Mouse Anti-CCNL1 Recombinant Antibody (CBYY-C1127) (CBMAB-C2564-YY)

Name: Mouse Anti-CCNL1 Recombinant Antibody (CBYY-C1127)
SKU: CBMAB-C2564-YY
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBYY-C1127

Antibody Isotype

IgG1, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Recombinant cyclin L1 of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.1 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

cyclin L1

Entrez Gene ID

57018

UniProt ID

Q9UK58

Alternative Names

NEP; SFE; CD10; CALLA; CMT2T; SCA43

Function

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs) (PubMed:18216018).
Inhibited by the CDK-specific inhibitor CDKN1A/p21 (PubMed:11980906).
May play a role in the regulation of RNA polymerase II (pol II). May be a candidate proto-oncogene in head and neck squamous cell carcinomas (HNSCC) (PubMed:12414649, PubMed:15700036).

Biological Process

Regulation of transcription by RNA polymerase II Source: GO_Central
RNA processing Source: InterPro

Cellular Location

Nucleus speckle; Nucleoplasm. Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.

More Infomation

References

Zeng, X., Hu, Z., Shen, Y., Wei, X., Gan, J., & Liu, Z. (2020). MiR-5195-3p Functions as a Tumor Suppressor in Prostate Cancer via Targeting CCNL1.

Liu, T. H., Wu, Y. F., Dong, X. L., Pan, C. X., Du, G. Y., Yang, J. G., ... & Lu, C. (2017). Identification and characterization of the BmCyclin L1-BmCDK11A/B complex in relation to cell cycle regulation. Cell Cycle, 16(9), 861-868.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

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