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Rabbit Anti-CCNH Recombinant Antibody (CBFYC-1056) (CBMAB-C1113-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBFYC-1056
Antibody Isotype
IgG
Application
ELISA, IF, IHC-P, WB

Basic Information

Immunogen
A synthetic peptide corresponding to a sequence within amino acids 224-323 of human Cyclin H.
Host Species
Rabbit
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000
IHC-P1:50-1:200
IF(ICC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA,50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-110

Target

Full Name
Cyclin H
Introduction
CCNH (Cyclin H) is a Protein Coding gene. Diseases associated with CCNH include Breast Cancer and Fructose Intolerance, Hereditary. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance and Formation of HIV elongation complex in the absence of HIV Tat. Gene Ontology (GO) annotations related to this gene include protein kinase binding and DNA-dependent ATPase activity.
Entrez Gene ID
902
UniProt ID
P51946
Alternative Names
Cyclin H; MO15-Associated Protein; Cyclin-Dependent Kinase-Activating Kinase Complex Subunit; CDK-Activating Kinase Complex Subunit; CAK Complex Subunit; P34
Function
Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle.
Biological Process
7-methylguanosine mRNA capping Source: Reactome
G1/S transition of mitotic cell cycle Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Nucleotide-excision repair, preincision complex assembly Source: Reactome
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Protein stabilization Source: CAFA
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription by RNA polymerase II Source: GO_Central
Termination of RNA polymerase I transcription Source: Reactome
Transcription by RNA polymerase II Source: UniProtKB
Transcription-coupled nucleotide-excision repair Source: Reactome
Transcription elongation from RNA polymerase II promoter Source: Reactome
Transcription initiation from RNA polymerase II promoter Source: ARUK-UCL
Transcription initiation from RNA polymerase I promoter Source: Reactome
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

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