Mouse Anti-CCL15 Recombinant Antibody (CBFYM-0904) (CBMAB-M1052-FY)

Name: Mouse Anti-CCL15 Recombinant Antibody (CBFYM-0904)
SKU: CBMAB-M1052-FY
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CCL15 Recombinant Antibody (CBFYM-0904) (CBMAB-M1052-FY) in IF

Representative images of total WBCs and isolated subsets slides of Wright-Giemsa staining and immunofluorescence staining for EPX (green), hCCL23 (red), hCCL15 (red), and DAPI (blue). Scale bar, 40μm. ...View More

Du, X., Li, F., Zhang, C., Li, N., Huang, H., Shao, Z., ... & Shen, H. (2021). Eosinophil-derived chemokine (hCCL15/23, mCCL6) interacts with CCR1 to promote eosinophilic airway inflammation. Signal transduction and targeted therapy, 6(1), 91.

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBFYM-0904

Antibody Isotype

IgM, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Amino acids 81-112 at the C-terminus of MIP-5 of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA	1:100-1:1,000
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

chemokine (C-C motif) ligand 15

Introduction

CCL15 is a Protein Coding gene. Diseases associated with CCL15 include Gastrointestinal System Cancer and Spherocytosis, Type 5. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology annotations related to this gene include receptor binding and chemokine activity. An important paralog of this gene is CCL15-CCL14.

Entrez Gene ID

6359

UniProt ID

Q16663

Alternative Names

C-C Motif Chemokine Ligand 15; Macrophage Inflammatory Protein 5; Chemokine CC-2; MIP-1 Delta; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 15; Chemokine (C-C Motif) Ligand 15; Small-Inducible Cytokine A15; Leukotactin 1; MRP-2B; SCYA15; HCC-2; LKN-1; MIP-5

Function

Chemotactic factor that attracts T-cells and monocytes, but not neutrophils, eosinophils, or B-cells. Acts mainly via CC chemokine receptor CCR1. Also binds to CCR3. CCL15(22-92), CCL15(25-92) and CCL15(29-92) are more potent chemoattractants than the small-inducible cytokine A15.

Biological Process

Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Secreted

More Infomation

References

Ni, Z., Lu, W., Li, Q., Han, C., Yuan, T., Sun, N., & Shi, Y. (2021). Analysis of the HNF4A isoform-regulated transcriptome identifies CCL15 as a downstream target in gastric carcinogenesis. Cancer biology & medicine, 18(2), 530.

Pang, N., Lin, Z., Wang, X., Xu, L., Xu, X., Huang, R., ... & Li, J. (2020). Endothelial cell‑derived CCL15 mediates the transmigration of fibrocytes through the CCL15‑CCR1 axis in vitro. Molecular Medicine Reports, 22(6), 5339-5347.

Watanabe, M., Horimasu, Y., Iwamoto, H., Yamaguchi, K., Sakamoto, S., Masuda, T., ... & Hattori, N. (2019). CC motif chemokine ligand 15 may be a useful biomarker for predicting the prognosis of patients with chronic hypersensitivity pneumonitis. Respiration, 98(3), 212-220.

Liu, L. Z., Zhang, Z., Zheng, B. H., Shi, Y., Duan, M., Ma, L. J., ... & Gao, Q. (2019). CCL 15 Recruits Suppressive Monocytes to Facilitate Immune Escape and Disease Progression in Hepatocellular Carcinoma. Hepatology, 69(1), 143-159.

Watanabe, M., Horimasu, Y., Iwamoto, H., Yamaguchi, K., Sakamoto, S., Masuda, T., ... & Hattori, N. (2019). Clinical utility of CCL15 as a prognostic biomarker for hypersensitivity pneumonitis.

Xu, X., Li, Y., Liang, Y., Yin, M., Zhang, Y., Huang, L., ... & Ni, J. (2018). Low responsiveness to a hepatitis B virus vaccine in a Chinese population lacks association with ITGAL, CD58, TNFSF15, CCL15, TGFB3, and BCL6 gene variants. Infection, Genetics and Evolution, 64, 126-130.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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