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Mouse Anti-CCL1 Recombinant Antibody (CBFYC-0917) (CBMAB-C0973-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0917
Antibody Isotype
IgG2a, κ
Application
ELISA, FC

Basic Information

Immunogen
Recombinant protein corresponding to human CCL-1.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.09% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 1
Introduction
CCL1 (C-C Motif Chemokine Ligand 1) is a Protein Coding gene. Diseases associated with CCL1 include Igg4-Related Sclerosing Cholangitis and Tolosa-Hunt Syndrome. Among its related pathways are PEDF Induced Signaling and Aryl Hydrocarbon Receptor. Gene Ontology (GO) annotations related to this gene include cytokine activity and chemokine activity.
Entrez Gene ID
6346
UniProt ID
P22362
Alternative Names
C-C Motif Chemokine Ligand 1; T Lymphocyte-Secreted Protein I-309; Small Inducible Cytokine A1 (I-309, Homologous To Mouse Tca-3); Chemokine (C-C Motif) Ligand 1; Inflammatory Cytokine I-309; SCYA1; Small-Inducible Cytokine A1
Function
Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Eosinophil chemotaxis Source: GO_Central
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cytosolic calcium ion concentration Source: CAFA
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of inflammatory response Source: BHF-UCL
Positive regulation of interleukin-17 production Source: BHF-UCL
Positive regulation of monocyte chemotaxis Source: CAFA
Signal transduction Source: ProtInc
Viral process Source: ProtInc
Cellular Location
Secreted
More Infomation

Fujikawa, M., Koma, Y. I., Hosono, M., Urakawa, N., Tanigawa, K., Shimizu, M., ... & Yokozaki, H. (2021). Chemokine (CC Motif) Ligand 1 Derived from Tumor-Associated Macrophages Contributes to Esophageal Squamous Cell Carcinoma Progression via CCR8-Mediated Akt/Proline-Rich Akt Substrate of 40 kDa/Mammalian Target of Rapamycin Pathway. The American Journal of Pathology, 191(4), 686-703.

García‐Domínguez, M., González‐Rodríguez, S., Hidalgo, A., Baamonde, A., & Menéndez, L. (2021). Kappa‐opioid receptor‐mediated thermal analgesia evoked by the intrathecal administration of the chemokine CCL1 in mice. Fundamental & Clinical Pharmacology.

Ding, S., Li, H., Li, X., Wang, W., Du, X., Dong, G., & Zhang, P. (2021). Retracted “Serum amyloid P down-regulates CCL-1 expression, and inhibits Ras/MAPK signaling and development of breast cancer”. Tropical Journal of Pharmaceutical Research, 20(10), 2235-2235.

Komatsu, M., Yamamoto, H., Yasuo, M., Ushiki, A., Nakajima, T., Uehara, T., ... & Hanaoka, M. (2020). The utility of serum CC chemokine ligand 1 in sarcoidosis: A comparison to IgG4-related disease. Cytokine, 133, 155123.

Zhong, L., Xiao, W., Wang, F., Liu, J., & Zhi, L. J. (2019). miR‐21‐5p inhibits neuropathic pain development via directly targeting C‐C motif ligand 1 and tissue inhibitor of metalloproteinase‐3. Journal of cellular biochemistry, 120(10), 16614-16623.

Yamamoto, H., Yasuo, M., Komatsu, M., Ushiki, A., Hamano, H., Hori, A., ... & Hanaoka, M. (2019). Comparison of the chemokine profiles in the bronchoalveolar lavage fluid between IgG4-related respiratory disease and sarcoidosis: CC-chemokine ligand 1 might be involved in the pathogenesis of sarcoidosis. Cytokine, 120, 125-129.

García-Domínguez, M., Aguirre, A., Lastra, A., Hidalgo, A., Baamonde, A., & Menéndez, L. (2019). The Systemic administration of the chemokine CCL1 evokes thermal analgesia in mice through the activation of the endocannabinoid system. Cellular and molecular neurobiology, 39(8), 1115-1124.

Ding, S., Li, H., Li, X., Wang, W., Du, X., Dong, G., & Zhang, P. (2017). Serum amyloid P down-regulates CCL-1 expression, and inhibits Ras/MAPK signaling and development of breast cancer. Tropical Journal of Pharmaceutical Research, 16(9), 2089-2095.

Saito, M., Sejima, H., Naito, T., Ushirogawa, H., Matsuzaki, T., Matsuura, E., ... & Takashima, H. (2017). The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. Virology journal, 14(1), 1-12.

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For research use only. Not intended for any clinical use.

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