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Mouse Anti-CCKAR Recombinant Antibody (EG509) (CBMAB-EN577-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
EG509
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 1-60 mapping at the N-terminus of CCK-AR of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cholecystokinin A Receptor
Introduction
CCKAR (Cholecystokinin A Receptor) is a Protein Coding gene. Diseases associated with CCKAR include Panic Disorder and Dyspepsia. Among its related pathways are Peptide ligand-binding receptors and Pancreatic secretion. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cholecystokinin receptor activity. An important paralog of this gene is CCKBR.
Entrez Gene ID
Human886
Mouse12425
Rat24889
UniProt ID
HumanP32238
MouseO08786
RatP30551
Alternative Names
Cholecystokinin A Receptor; Cholecystokinin-1 Receptor; CCK-A Receptor; CCK-AR; CCK1-R; CCKRA;
Function
Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Biological Process
Axonogenesis Source: Ensembl
Cholecystokinin signaling pathway Source: GO_Central
Forebrain development Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Neuron migration Source: Ensembl
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: ProtInc
Regulation of hormone secretion Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-41
Helical: 42-67
Cytoplasmic: 68-77
Helical: 78-104
Extracellular: 105-115
Helical: 116-137
Cytoplasmic: 138-157
Helical: 158-178
Extracellular: 179-210
Helical: 211-234
Cytoplasmic: 235-313
Helical: 314-334
Extracellular: 335-349
Helical: 350-373
Cytoplasmic: 374-428
More Infomation

Pangniban, R., Sun, M., Park, C. Y., Koh, A., Kasahara, D., Israel, E., ... & Lu, Q. (2021). Antagonizing the metabolic hormone cholecystokinin (CCK) and its receptor CCKAR in the lung abolishes obesity-induced airway hyperresponsiveness.

Wang, H. H., Portincasa, P., Liu, M., Tso, P., & Wang, D. Q. H. (2020). An Update on the Lithogenic Mechanisms of Cholecystokinin a Receptor (CCKAR), an Important Gallstone Gene for Lith13. Genes, 11(12), 1438.

Rikimaru, K., Sato, Y., Ito, Y., Fukuda, S., Sasaki, S., & Takahashi, H. (2020). Is a single nucleotide Polymorphism marker in the cholecystokinin A receptor gene practically suitable for improving the growth traits of Hinai-jidori chickens?. The Journal of Poultry Science, 57(2), 99-106.

Kim, H. T., Sacotte, S., Williams, R. A., De Souza, A. H., Han, J. Y., Bartosiak, J. T., ... & Davis, D. B. (2019). 2137-P: Cholecystokinin Protects Mouse Pancreatic Beta Cells against Cytokine Insult through the Cholecystokinin A Receptor.

Panganiban, R. A. M., Sun, M., Park, C. Y., Kasahara, D. I., Himes, B. E., Israel, E., ... & Lu, Q. (2018). Targeting cholecystokinin (CCK) and its receptor CCKAR in the airway smooth muscle for new asthma therapy. In B20. ASTHMA: NEW FINDINGS IN AIRWAY SMOOTH MUSCLE PATHOPHYSIOLOGY AND POTENTIAL THERAPY (pp. A2744-A2744). American Thoracic Society.

Yi, Z., Li, X., Luo, W., Xu, Z., Ji, C., Zhang, Y., ... & Zhang, X. (2018). Feed conversion ratio, residual feed intake and cholecystokinin type A receptor gene polymorphisms are associated with feed intake and average daily gain in a Chinese local chicken population. Journal of animal science and biotechnology, 9(1), 1-9.

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For research use only. Not intended for any clinical use.

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