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Mouse Anti-CBLL1 Recombinant Antibody (CBYY-C1029) (CBMAB-C2466-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-C1029
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 1-100 representing partial length CBLL1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Entrez Gene ID
79872
UniProt ID
Q75N03
Alternative Names
C-C Motif Chemokine Ligand 11; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 11 (Eotaxin); Chemokine (C-C Motif) Ligand 11; Eosinophil Chemotactic Protein; Eotaxin-1; SCYA11; Small-Inducible Cytokine A11; C-C Motif Chemokine 11; Eotaxin;
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity).
Targets CDH1 for endocytosis and degradation (By similarity).
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Its function in the WMM complex is unknown (PubMed:29507755).
Biological Process
Cell-cell adhesion Source: UniProtKB
Entry of bacterium into host cell Source: Reactome
mRNA methylation Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of cell adhesion Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of endocytosis Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of cell adhesion Source: GO_Central
Cellular Location
Cytoplasm; Nucleus speckle; Nucleoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
PTM
Phosphorylated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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