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Mouse Anti-CBLL1 Recombinant Antibody (CBXC-1721) (CBMAB-C5462-CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBXC-1721
Antibody Isotype
IgG2a, κ
Application
WB, IF, ELISA

Basic Information

Immunogen
CBLL1 (1 a.a. ~ 100 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1
Introduction
This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant.
Entrez Gene ID
79872
UniProt ID
Q75N03
Alternative Names
Cbl Proto-Oncogene Like 1; Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence-Like 1; Casitas B-Lineage Lymphoma-Transforming Sequence-Like Protein 1; Cbl Proto-Oncogene Like 1, E3 Ubiquitin Protein Ligase; RING-Type E3 Ubiquitin Transferase Hakai; RING Finger Protein 188; C-Cbl-Like Protein 1; RNF188; HAKAI;
Function
E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (By similarity).
Targets CDH1 for endocytosis and degradation (By similarity).
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29507755).
Its function in the WMM complex is unknown (PubMed:29507755).
Biological Process
Cell-cell adhesion Source: UniProtKB
Entry of bacterium into host cell Source: Reactome
mRNA methylation Source: UniProtKB
Multicellular organism development Source: UniProtKB-KW
Negative regulation of cell adhesion Source: UniProtKB
Positive regulation of cell migration Source: UniProtKB
Positive regulation of endocytosis Source: UniProtKB
Protein ubiquitination Source: GO_Central
Regulation of cell adhesion Source: GO_Central
Cellular Location
Cytoplasm; Nucleus speckle; Nucleoplasm. Mainly nuclear with some fraction located in the cytoplasm. ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus.
PTM
Phosphorylated on tyrosine residues.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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