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Mouse Anti-CAP1 Recombinant Antibody (CBXC-0059) (CBMAB-C3199-CQ)


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Published Data
CBMAB-C3199-CQ-1
Mouse Anti-CAP1 Recombinant Antibody (CBXC-0059) (CBMAB-C3199-CQ) in Immunoblot
Immunoblot analysis of XLalphas, CAP1 and Gsalpha protein in platelet lysates from XL hypermethylated AHO-like patients 12, 13, 10, 14, 15, 16 and 3 controls. ...View More
Izzi, B., Francois, I., Labarque, V., Thys, C., Wittevrongel, C., Devriendt, K., ... & Freson, K. (2012). Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunction. PloS one, 7(6), e38579.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0059
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IP

Basic Information

Immunogen
Recombinant CAP1 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclase Associated Actin Cytoskeleton Regulatory Protein 1
Introduction
CAP1 (Cyclase Associated Actin Cytoskeleton Regulatory Protein 1) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Signaling by Robo receptor. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAP2.
Entrez Gene ID
10487
UniProt ID
Q01518
Alternative Names
Cyclase Associated Actin Cytoskeleton Regulatory Protein 1; Adenylate Cyclase Associated Protein 1; CAP; CAP, Adenylate Cyclase-Associated Protein 1 (Yeast); Testis Secretory Sperm-Binding Protein Li 218p; CAP, Adenylate Cyclase-Associated Protein 1; Adenylyl Cyclase-Associated Protein 1; CAP1-PEN; CAP 1;
Function
Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
Biological Process
Actin cytoskeleton organization Source: Ensembl
Activation of adenylate cyclase activity Source: ProtInc
Ameboidal-type cell migration Source: Ensembl
cAMP-mediated signaling Source: GO_Central
Cell morphogenesis Source: GO_Central
Establishment or maintenance of cell polarity Source: ProtInc
Neutrophil degranulation Source: Reactome
Receptor-mediated endocytosis Source: Ensembl
Regulation of adenylate cyclase activity Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
More Infomation

Schneider, F., Duong, T. A., Metz, I., Winkelmeier, J., Hübner, C. A., Endesfelder, U., & Rust, M. B. (2021). Mutual functional dependence of cyclase-associated protein 1 (CAP1) and cofilin1 in neuronal actin dynamics and growth cone function. Progress in Neurobiology, 202, 102050.

Zhang, X., Pizzoni, A., Hong, K., Naim, N., Qi, C., Korkhov, V., & Altschuler, D. L. (2021). CAP1 binds and activates adenylyl cyclase in mammalian cells. Proceedings of the National Academy of Sciences, 118(24).

Zhang, H., Ramsey, A., Xiao, Y., Karki, U., Xie, J. Y., Xu, J., ... & Zhou, G. L. (2020). Dynamic phosphorylation and dephosphorylation of cyclase-associated protein 1 by antagonistic signaling through cyclin-dependent kinase 5 and cAMP are critical for the protein functions in actin filament disassembly and cell adhesion. Molecular and cellular biology, 40(4), e00282-19.

Bergqvist, M., Elebro, K., Sandsveden, M., Borgquist, S., & Rosendahl, A. H. (2020). Effects of tumor-specific CAP1 expression and body constitution on clinical outcomes in patients with early breast cancer. Breast Cancer Research, 22(1), 1-15.

Yuan, X., Zhen, Z., Zhang, M., Yu, Y., Gao, X., & Ao, J. X. (2019). Cyclase‐associated protein 1 is a key negative regulator of milk synthesis and proliferation of bovine mammary epithelial cells. Cell biochemistry and function, 37(3), 185-192.

Hasan, R., & Zhou, G. L. (2019). The cytoskeletal protein cyclase-associated protein 1 (CAP1) in breast cancer: context-dependent roles in both the invasiveness and proliferation of cancer cells and underlying cell signals. International journal of molecular sciences, 20(11), 2653.

Wu, H., Hasan, R., Zhang, H., Gray, J., Williams, D., Miller, M., ... & Zhou, G. L. (2019). Phosphorylation regulates CAP1 (cyclase-associated protein 1) functions in the motility and invasion of pancreatic cancer cells. Scientific reports, 9(1), 1-13.

Kakurina, G. V., Kolegova, E. S., & Kondakova, I. V. (2018). Adenylyl cyclase-associated protein 1: structure, regulation, and participation in cellular processes. Biochemistry (Moscow), 83(1), 45-53.

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For research use only. Not intended for any clinical use.

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