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Mouse Anti-CACNB3 Monoclonal Antibody (7D1) (CBMAB-0949-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
7D1
Antibody Isotype
IgG1, κ
Application
WB, IH, IP, IF, FC

Basic Information

Immunogen
Recombinant L-type Ca++ CP β3 of rat origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 3
Introduction
CACNB3 is a regulatory beta subunit of the voltage-dependent calcium channel, which are composed of five domains and contribute to the regulation of surface expression and gating of calcium channels. CACNB3 may also play a role in the regulation of transcription factors and calcium transport.
Entrez Gene ID
12297
UniProt ID
P54285
Alternative Names
CAB3; Beta3; Cchb3; Ca(v)beta3
Function
Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8119293).
Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
Biological Process
Calcium ion transmembrane transport via high voltage-gated calcium channel Source: UniProtKB
Calcium ion transport Source: UniProtKB
Calcium ion transport into cytosol Source: BHF-UCL
Cellular response to oxygen-glucose deprivation Source: Ensembl
Chemical synaptic transmission Source: GO_Central
Detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
Membrane depolarization Source: Reactome
Negative regulation of detection of mechanical stimulus involved in sensory perception of touch Source: Ensembl
Negative regulation of voltage-gated calcium channel activity Source: Ensembl
Neuromuscular junction development Source: GO_Central
Positive regulation of excitatory postsynaptic potential Source: Ensembl
Positive regulation of high voltage-gated calcium channel activity Source: UniProtKB
Positive regulation of protein targeting to membrane Source: Ensembl
Protein localization to plasma membrane Source: BHF-UCL
Regulation of membrane hyperpolarization Source: Ensembl
Regulation of membrane repolarization during action potential Source: BHF-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central
T cell receptor signaling pathway Source: Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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