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Mouse Anti-CACNB1 Recombinant Antibody (CBFYC-0722) (CBMAB-C0777-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYC-0722
Antibody Isotype
IgG2a, κ
Application
WB, IP, E

Basic Information

Immunogen
Recombinant L-type Ca++ CP β1 protein of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1
Introduction
CACNB1 (Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1) is a Protein Coding gene. Diseases associated with CACNB1 include Malignant Hyperthermia and Malignant Hyperthermia Susceptibility. Among its related pathways are Cardiac conduction and NFAT and Cardiac Hypertrophy. Gene Ontology (GO) annotations related to this gene include voltage-gated calcium channel activity and high voltage-gated calcium channel activity. An important paralog of this gene is CACNB2.
Entrez Gene ID
782
UniProt ID
Q02641
Alternative Names
Calcium Voltage-Gated Channel Auxiliary Subunit Beta 1; Calcium Channel, Voltage-Dependent, Beta 1 Subunit; Calcium Channel Voltage-Dependent Subunit Beta 1; CACNLB1; CAB1; Dihydropyridine-Sensitive L-Type, Calcium Channel Beta-1 Subunit; Voltage-Dependent L-Type Calcium Channel Subunit Beta-1; Calcium Channel, L Type, Beta 1 Polypeptide; CCHLB1
Function
Regulatory subunit of L-type calcium channels (PubMed:1309651, PubMed:8107964, PubMed:15615847).
Regulates the activity of L-type calcium channels that contain CACNA1A as pore-forming subunit (By similarity).
Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit and increases the presence of the channel complex at the cell membrane (PubMed:15615847).
Required for functional expression L-type calcium channels that contain CACNA1D as pore-forming subunit (PubMed:1309651).
Regulates the activity of L-type calcium channels that contain CACNA1B as pore-forming subunit (PubMed:8107964).
Biological Process
Cardiac conduction Source: Reactome
Cellular response to amyloid-beta Source: ARUK-UCL
Chemical synaptic transmission Source: GO_Central
Neuromuscular junction development Source: GO_Central
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel Source: ARUK-UCL
Regulation of voltage-gated calcium channel activity Source: GO_Central
Cellular Location
Sarcolemma; Cell membrane
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For research use only. Not intended for any clinical use.

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