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Rabbit Anti-CAB39 Recombinant Antibody (CBLC275-LY) (CBMAB-C9598-LY)


See all CAB39 antibodies
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Published Data
CBMAB-C9598-LY-1
Rabbit Anti-CAB39 Recombinant Antibody (CBLC275-LY) (CBMAB-C9598-LY) in WB
Binding to both STRADα and MO25 (F148S, G163R, P179R, A241P, G242V, W308R) while two variants at position R297 (R297M and R297S) did not bind to STRADα but retained the ability to interact with MO25. ...View More
Donnelly, L. L., Hogan, T. C., Lenahan, S. M., Nandagopal, G., Eaton, J. G., Lebeau, M. A., ... & Seward, D. J. (2021). Functional assessment of somatic STK11 variants identified in primary human non-small cell lung cancers. Carcinogenesis, 42(12), 1428-1438.
CBMAB-C9598-LY-2
Rabbit Anti-CAB39 Recombinant Antibody (CBLC275-LY) (CBMAB-C9598-LY) in WB
Tankyrase inhibitor treatment enhances LKB1/STRAD/MO25 complex formation. HEK293A cells were treated with DMSO or the tankyrase inhibitors JW55. WIKI4, XAV939, or G007-LK, and subjected to immunoprecipitation/western blotting. We use the ImageJ to calculate the band densitometry of western blots, and get the relative ratio by comparing the densitometry of MO25/LKB1 or STRAD/LKB1, and we get three relative ratios from three independent experiments. ...View More
Li, N., Wang, Y., Neri, S., Zhen, Y., Fong, L. W. R., Qiao, Y., ... & Lin, S. H. (2019). Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nature communications, 10(1), 4363.
CBMAB-C9598-LY-3
Rabbit Anti-CAB39 Recombinant Antibody (CBLC275-LY) (CBMAB-C9598-LY) in Immunoblot
Primary mouse aortic smooth muscle cells were transfected with synthetic mature mimics of either miR-144 (100 nM), miR-451 (100 nM) or miR-144+miR-451 (50 nM each). After 96 hours, the cell lysates were immunoblotted with anti-MO25α/CAB39. ...View More
Turczyńska, K. M., Bhattachariya, A., Säll, J., Göransson, O., Swärd, K., Hellstrand, P., & Albinsson, S. (2013). Stretch-sensitive down-regulation of the miR-144/451 cluster in vascular smooth muscle and its role in AMP-activated protein kinase signaling. PLoS one, 8(5), e65135.

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBLC275-LY
Antibody Isotype
IgG
Application
IP, WB

Basic Information

Immunogen
Synthetic peptide corresponding to the sequence of human MO25α/CAB39.
Host Species
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:1,000
IP1:50

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
HEPES, pH 7.5, 100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calcium Binding Protein 39
Introduction
CAB39 (Calcium Binding Protein 39) is a Protein Coding gene. Among its related pathways are Innate Immune System and RET signaling. Gene Ontology (GO) annotations related to this gene include binding and kinase binding. An important paralog of this gene is CAB39L.
Entrez Gene ID
Human51719
Rat301574
Mouse12283
UniProt ID
HumanQ9Y376
RatD3ZJ77
MouseQ06138
Alternative Names
Calcium Binding Protein 39; MO25alpha; MO25; Calcium-Binding Protein 39; Protein Mo25; CGI-66;
Function
Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.
Biological Process
Cell cycle arrest Source: Reactome
Cellular hypotonic response Source: ParkinsonsUK-UCL
Intracellular signal transduction Source: ParkinsonsUK-UCL
Negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
Negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
Neutrophil degranulation Source: Reactome
Peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
Positive regulation of protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
Response to activity Source: Ensembl
Response to thyroid hormone Source: Ensembl
Signal transduction Source: ParkinsonsUK-UCL
Cellular Location
Cytoplasm
More Infomation

Zhang, S., Zhang, R., Qiao, P., Ma, X., Lu, R., Wang, F., ... & Liu, H. (2021). Metformin-induced MicroRNA-34a-3p downregulation alleviates senescence in human dental pulp stem cells by targeting CAB39 through the AMPK/mTOR signaling pathway. Stem Cells International, 2021.

Chao, H., Peng, L., Deng, L., Yu, Z., Deng, H., Xu, F., ... & Zeng, T. (2021). CAB39 mediates epithelial-mesenchymal transition via activation of NF-κB signaling to facilitate bladder cancer invasion and metastasis.

Liang, Y., Zhu, D., Hou, L., Wang, Y., Huang, X., Zhou, C., ... & Meng, X. (2020). MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39. British journal of cancer, 122(5), 705-714.

Zhuang, Y., Wang, S., Fei, H., Ji, F., & Sun, P. (2020). miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. Aging (Albany NY), 12(12), 11754.

Jiang, W. L., Zhao, K. C., Yuan, W., Zhou, F., Song, H. Y., Liu, G. L., ... & Xie, S. P. (2020). MicroRNA-31-5p exacerbates lipopolysaccharide-induced acute lung injury via inactivating Cab39/AMPKα pathway. Oxidative medicine and cellular longevity, 2020.

Li, K., Cao, J., Zhang, Z., Chen, K., Ma, T., Yang, W., ... & Zhang, K. (2020). Circular RNA circGSK3B Promotes Cell Proliferation, Migration, and Invasion by Sponging miR-1265 and Regulating CAB39 Expression in Hepatocellular Carcinoma. Frontiers in oncology, 10, 2465.

Peng, L., Yan, H., Qi, S., & Deng, L. (2020). CAB39 Promotes the Proliferation of Nasopharyngeal Carcinoma CNE-1 Cells via Up-Regulating p-JNK. Cancer Management and Research, 12, 11203.

Xu, Z., Li, Z., Wang, W., Xia, Y., He, Z., Li, B., ... & Xu, Z. (2019). MIR-1265 regulates cellular proliferation and apoptosis by targeting calcium binding protein 39 in gastric cancer and, thereby, impairing oncogenic autophagy. Cancer letters, 449, 226-236.

Yang, F., Liu, S., Sun, J., & Wang, G. (2018). microRNA-22 Promotes the Osteogenic Differentiation of Valvular Interstitial Cells by Targeting Calcium Binding Protein 39. Circulation, 138(Suppl_1), A11504-A11504.

Jiang, L., Yan, Q., Fang, S., Liu, M., Li, Y., Yuan, Y. F., ... & Guan, X. Y. (2017). Calcium‐binding protein 39 promotes hepatocellular carcinoma growth and metastasis by activating extracellular signal‐regulated kinase signaling pathway. Hepatology, 66(5), 1529-1545.

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For research use only. Not intended for any clinical use.

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