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Mouse Anti-BRK1 Recombinant Antibody (CBYY-C0776) (CBMAB-C2212-YY)


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Published Data
CBMAB-C2212-YY-1
CBMAB-C2212-YY in IHC
Expression of Nckap1l and other WRC proteins in the liver of wild-type and nckap1llri35 mutant larvae. ...View More
Ghaffari, K., Pierce, L. X., Roufaeil, M., Gibson, I., Tae, K., Sahoo, S., ... & Sakaguchi, T. F. (2021). NCK-associated protein 1 like (nckap1l) minor splice variant regulates intrahepatic biliary network morphogenesis. PLoS Genetics, 17(3), e1009402.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-C0776
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 1-75 representing full length HSPC300 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
BRICK1, SCAR/WAVE Actin Nucleating Complex Subunit
Entrez Gene ID
55845
UniProt ID
Q8WUW1
Alternative Names
AHUS5, ARMD9, ASPa, C3b, CPAMD1, HEL-S-62p, C3
Function
Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity).
Biological Process
Actin filament organization Source: InterPro
Cell motility Source: GO_Central
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
In utero embryonic development Source: Ensembl
Positive regulation of Arp2/3 complex-mediated actin nucleation Source: UniProtKB
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of lamellipodium assembly Source: ARUK-UCL
Positive regulation of protein-containing complex assembly Source: UniProtKB
Rac protein signal transduction Source: UniProtKB
Regulation of actin polymerization or depolymerization Source: GO_Central
Vascular endothelial growth factor receptor signaling pathway Source: Reactome
Cellular Location
Cytoskeleton
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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