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Mouse Anti-BOD1L1 Recombinant Antibody (CBXF-1700) (CBMAB-F3235-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1700
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, E

Basic Information

Immunogen
Amino acids 466-530 mapping within an internal region of FAM44A of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Biorientation Of Chromosomes In Cell Division 1 Like 1
Introduction
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBXO18/FBH1 and BLM (PubMed:26166705). Does not regulate spindle orientation (PubMed:26166705).
Entrez Gene ID
259282
UniProt ID
Q8NFC6
Alternative Names
Biorientation Of Chromosomes In Cell Division 1 Like 1; Biorientation Of Chromosomes In Cell Division 1-Like; Family With Sequence Similarity 44, Member A; FAM44A; BOD1L; Biorientation Of Chromosomes In Cell Division Protein 1-Like 1; KIAA1327;
Function
Component of the fork protection machinery required to protect stalled/damaged replication forks from uncontrolled DNA2-dependent resection. Acts by stabilizing RAD51 at stalled replication forks and protecting RAD51 nucleofilaments from the antirecombinogenic activities of FBH1 and BLM (PubMed:26166705).
Does not regulate spindle orientation (PubMed:26166705).
Biological Process
Cellular response to DNA damage stimulus Source: UniProtKB
DNA repair Source: UniProtKB-KW
Negative regulation of phosphoprotein phosphatase activity Source: GO_Central
Replication fork processing Source: UniProtKB
Cellular Location
Chromosome. Localizes at replication forks: following DNA damage, localizes to damaged replication forks undergoing resection.
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For research use only. Not intended for any clinical use.

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