Mouse Anti-BICC1 Recombinant Antibody (CBYY-0556) (CBMAB-0559-YY)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Mouse, Rat

Clone

CBYY-0556

Antibody Isotype

IgG1, κ

Application

WB, IP, IF, ELISA

Basic Information

Immunogen

Amino acids 243-480 mapping within an internal region of BICC1 of human origin.

Host Species

Mouse

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:100-1:1,000
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500
ELISA	1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

BicC Family RNA Binding Protein 1

Introduction

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

Entrez Gene ID

80114

UniProt ID

Q9H694

Alternative Names

BicC Family RNA Binding Protein 1; Bicaudal C Homolog 1 (Drosophila); FGFR2-BICC1 Fusion Kinase Protein; Protein Bicaudal C Homolog 1; Bicaudal C Homolog 1; CYSRD; Bic-C; BICC;

Function

Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development.

Biological Process

Determination of left/right symmetry Source: Ensembl
Heart development Source: Ensembl
Kidney development Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB

Cellular Location

Cytoplasm

Involvement in disease

Renal dysplasia, cystic (CYSRD): An anomaly of the kidney characterized by numerous renal cysts and apparent disorder of differentiation of the renal parenchyma. Kidney of affected individuals lack the normal renal bean shape, and the collection drainage system. The cystic, dysplastic kidney contains undifferentiated mesenchyme, cartilaginous tissue, and immature collecting ducts.

More Infomation

References

Zhao, R., Peng, C., Song, C., Zhao, Q., Rong, J., Wang, H., ... & Xie, Y. (2020). BICC1 as a novel prognostic biomarker in gastric cancer correlating with immune infiltrates. International Immunopharmacology, 87, 106828.

Rothé, B., Gagnieux, C., Leal-Esteban, L. C., & Constam, D. B. (2020). Role of the RNA-binding protein Bicaudal-C1 and interacting factors in cystic kidney diseases. Cellular signalling, 68, 109499.

Wang, H., Guo, Y., Mi, N., & Zhou, L. (2020). miR-101-3p and miR-199b-5p promote cell apoptosis in oral cancer by targeting BICC1. Molecular and cellular probes, 52, 101567.

Hepei, L., Mingkun, X., Li, W., & Jin, W. (2017). Assessment of BicC family RNA binding protein 1 and Ras protein specific guanine nucleotide releasing factor 1 as candidate genes for high myopia: a case–control study. Indian journal of ophthalmology, 65(10), 926.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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