Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-BFSP1 Recombinant Antibody (CBYY-0508) (CBMAB-0511-YY)


See all BFSP1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0508
Antibody Isotype
IgG1, κ
Application
WB, IF, IP

Basic Information

Immunogen
Lens filament of bovine origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Beaded Filament Structural Protein 1
Introduction
This gene encodes a lens-specific intermediate filament-like protein named filensin. The encoded protein is expressed in lens fiber cells after differentiation has begun. This protein functions as a component of the beaded filament which is a cytoskeletal structure found in lens fiber cells. Mutations in this gene are the cause of autosomal recessive cortical juvenile-onset cataract. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
631
UniProt ID
Q12934
Alternative Names
Beaded Filament Structural Protein 1; Lens Fiber Cell Beaded-Filament Structural Protein CP 115; Beaded Filament Structural Protein 1, Filensin; Lens Intermediate Filament-Like Heavy; LIFL-H; CP115;
Function
Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (PubMed:28935373).
Involved in altering the calcium regulation of MIP water permeability (PubMed:30790544).
Biological Process
Cell maturation Source: Ensembl
Intermediate filament organization Source: UniProtKB
Lens fiber cell development Source: GO_Central
Cellular Location
Cytoskeleton; Cytoplasm; Cell membrane; Cell cortex
Involvement in disease
Cataract 33, multiple types (CTRCT33): An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. CTRCT33 has juvenile-onset and the opacities are restricted to the cortex of the lens, not involving the nucleus.
PTM
Proteolytically cleaved during lens cell fiber differentiation with increased fragmentation as fiber cell age increases.
Filensin C-terminal fragment: Myristoylated at Gly-434 following proteolytic cleavage at Asp-433.
Filensin N-terminal fragment: Acetylated at Ala-42 following proteolytic cleavage at Leu-41.
More Infomation
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-BFSP1 Recombinant Antibody (CBYY-0508)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry