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Mouse Anti-ARPC3 Recombinant Antibody (602.29cl.11) (CBMAB-0259-CN)


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Published Data
Mouse Anti-ARPC3 Recombinant Antibody (602.29cl.11) CBMAB-0259-CN in IF
Immunofluorescence using antibody against p16 and p21 was analyzed in the gingival epithelium of diabetic and control patients. Scale bar, 200 μm. ...View More
Zhang, P., Lu, B., Zhu, R., Yang, D., Liu, W., Wang, Q., ... & Wang, Q. (2021). Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation. Journal of Periodontal Research, 56(4), 667-678.
Mouse Anti-ARPC3 Recombinant Antibody (602.29cl.11) CBMAB-0259-CN in WB
Western blotting analysis showing p16- and p21-specific immunoreactivity in the gingival epithelium of diabetic and control mice. The optical density (O.D.) values of p16 and p21 levels relative to β-actin are represented in bar histograms. The data are means ±SD (n = 3). *p < 0.05 versus control mice. ...View More
Zhang, P., Lu, B., Zhu, R., Yang, D., Liu, W., Wang, Q., ... & Wang, Q. (2021). Hyperglycemia accelerates inflammaging in the gingival epithelium through inflammasomes activation. Journal of Periodontal Research, 56(4), 667-678.
Mouse Anti-ARPC3 Recombinant Antibody (602.29cl.11) CBMAB-0259-CN in WB
A172 cells were treated with 2 mM SB for the indicated time and the protein levels of the cell cycle regulators p21, p27 and p53 were analyzed by western blot analysis. ...View More
Nakagawa, H., Sasagawa, S., & Itoh, K. (2018). Sodium butyrate induces senescence and inhibits the invasiveness of glioblastoma cells. Oncology letters, 15(2), 1495-1502.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Dog, Cattle, Horse, Pig
Clone
602.29cl.11
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 1-178 representing full length p21-ARC of human origin.
Specificity
Human, Mouse, Rat, Dog, Cattle, Horse, Pig
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
actin related protein 2/3 complex, subunit 3, 21kDa
Introduction
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells. The protein functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Entrez Gene ID
10094
UniProt ID
O15145
Alternative Names
ARC21; p21-Arc
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).
In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947).
The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Biological Process
Actin polymerization-dependent cell motility Source: UniProtKB
Arp2/3 complex-mediated actin nucleation Source: FlyBase
Cellular response to nerve growth factor stimulus Source: Ensembl
Ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Membrane organization Source: Reactome
Cellular Location
Cytoskeleton; Nucleus; Cell projection
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For research use only. Not intended for any clinical use.

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