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Mouse Anti-ARPC3 Recombinant Antibody (26/p21-Arc) (CBMAB-P0074-YC)


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Published Data
Mouse Anti-ARPC3 Recombinant Antibody (26/p21-Arc) CBMAB-P0074-YC in WB
Western blot analysis of indicated proteins in cells with or without genipin (30 or 60 µM). Bar graphs demonstrate densitometric analysis of western blots from three independent experiments. *P<0.05 vs. vehicle-treated cells. ...View More
Li, Z., Zhang, T. B., Jia, D. H., Sun, W. Q., Wang, C. L., Gu, A. Z., & Yang, X. M. (2018). Genipin inhibits the growth of human bladder cancer cells via inactivation of PI3K/Akt signaling. Oncology letters, 15(2), 2619-2624.
Mouse Anti-ARPC3 Recombinant Antibody (26/p21-Arc) CBMAB-P0074-YC in WB
Western blot analysis of p21, p-Rb, CDK4, CDK6, cyclin D1 and cyclin A2 expression in DU145 cells indicated that overexpression of miR-1180 regulated the levels of these proteins. *P<0.05 and **P<0.01, vs. corresponding control group. ...View More
Zhu, D., Gao, W., & Zhang, Z. (2018). MicroRNA-1180 is associated with growth and apoptosis in prostate cancer via TNF receptor associated factor 1 expression regulation and nuclear factor-κB signaling pathway activation. Oncology letters, 15(4), 4775-4780.
Mouse Anti-ARPC3 Recombinant Antibody (26/p21-Arc) CBMAB-P0074-YC in WB
Expression of PRMT6, p21, CDK2, FAK and SRC protein was assessed by western blot analysis. ...View More
Zhao, X., Zhou, D., Liu, Y., Li, C., Zhao, X., Li, Y., & Li, W. (2018). Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway. Molecular medicine reports, 17(1), 147-157.

Summary

Host Animal
Mouse
Specificity
Human, Dog, Mouse, Rat
Clone
26/p21-Arc
Antibody Isotype
IgG1
Application
WB, IP, IF

Basic Information

Immunogen
Amino acids 10-118 of p21-ARC of human origin.
Specificity
Human, Dog, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
actin related protein 2/3 complex, subunit 3, 21kDa
Introduction
ARPC3 is one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been conserved through evolution and is implicated in the control of actin polymerization in cells.
Entrez Gene ID
Human10094
Mouse56378
Rat288669
Chicken416837
Dog100856747
UniProt ID
HumanO15145
MouseQ9JM76
RatB2GV73
ChickenE1C8Y3
DogE2R985
Alternative Names
Actin Related Protein 2/3 Complex Subunit 3; Arp2/3 Complex 21 KDa Subunit; P21-Arc; ARC21; Actin Related Protein 2/3 Complex, Subunit 3 (21 KD); Actin Related Protein 2/3 Complex, Subunit 3, 21kDa; Actin Related Protein 2/3 Complex Subunit 3, 21kDa; Actin-Related Protein 2/3 Complex Subunit 3; ARP2/3 Protein Complex Subunit P21;
Function
Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079).
The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079).
In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947).
The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947).
Biological Process
Actin polymerization-dependent cell motility Source: UniProtKB
Arp2/3 complex-mediated actin nucleation Source: FlyBase
Cellular response to nerve growth factor stimulus Source: Ensembl
Ephrin receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Membrane organization Source: Reactome
Cellular Location
Cytoskeleton; Nucleus; Cell projection
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For research use only. Not intended for any clinical use.

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