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Mouse Anti-AMH Recombinant Antibody (CBYC-A557) (CBMAB-A2530-YC)


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Published Data
Mouse Anti-AMH Recombinant Antibody (CBYC-A557) in IHC
Uterus masculinus, immunohistochemical findings: (A) Case number 3: Multifocal-cytoplasmic AMH staining in the simple columnar epithelium of the uterine mucosa. Bar 100 µm. (B) Case number 2: Diffuse-negative immunolabelling of the uterine squamous epithelium and simultaneous strong glandular expression of AMH. Bar 100 µm. (C) Case number 1: Diffuse-strong glandular and epithelial AMH immunolabelling. (A-C): Under 10× magnification, bar 100 µm. ...View More
Tura, G., Ballotta, G., Cunto, M., Orioles, M., Sarli, G., & Zambelli, D. (2023). Clinical and Histological Findings of Male Uterus (Uterus Masculinus) in Three Dogs (2014-2018). Animals, 13(4), 710.
Mouse Anti-AMH Recombinant Antibody (CBYC-A557) in IF
AMH and SOX9 immunostaining of porcine testis sections at each age. Bar = 10 μm. ...View More
Zheng, Y., Gao, Q., Li, T., Liu, R., Cheng, Z., Guo, M., ... & Zeng, W. (2022). Sertoli cell and spermatogonial development in pigs. Journal of Animal Science and Biotechnology, 13(1), 45.
Mouse Anti-AMH Recombinant Antibody (CBYC-A557) in IHC
Expression of FUS, PA2G4 and TRA2β in 6 month old wildtype and FXPOI mice. (A) Representative images of FUS, PA2G4 and TRA2β expression in 6 month old wildtype and CAG LoxP 5'UTR FMR1 (CGG)99x GFP x CMV Cre bigenic mice (referred to as FXPOI mice). Oocyte nuclei and cytoplasm are denoted with a red arrow head and pink asterisks, respectively, and granulosa cells, with a yellow arrow head. Scale bars represent 100 μM. (B) Quantification of mean gray values for FUS, PA2G4 and TRA2β representative of staining intensity were normalized to mean gray values of AMH (for granulosa cell data) and MSY2 (for oocyte data). Data are presented as the mean ± SEM from three separate mice. Mann-Whitney test, ****p < .0001 **p = .002. ...View More
Rosario, R., Stewart, H. L., Choudhury, N. R., Michlewski, G., Charlet-Berguerand, N., & Anderson, R. A. (2022). Evidence for a fragile X messenger ribonucleoprotein 1 (FMR1) mRNA gain-of-function toxicity mechanism contributing to the pathogenesis of fragile X-associated premature ovarian insufficiency. The FASEB Journal, 36(11).
Mouse Anti-AMH Recombinant Antibody (CBYC-A557) in WB
The expression levels of six proteins within the whole ovaries as determined by Western blots. Control, 0.1 mL of normal saline; Cp 50, cyclophosphamide 50 mg/kg; Cp 75, cyclophosphamide 75 mg/kg; Ima 7.5, imatinib 7.5 mg/kg; Ima 15, imatinib 15 mg/kg; AMH, anti-Müllerian hormone; A-SMase, acid sphingomyelinase; α-SMA, α-smooth muscle actin. ...View More
Kim, S. J., Kim, T. E., & Jee, B. C. (2022). Impact of imatinib administration on the mouse ovarian follicle count and levels of intra-ovarian proteins related to follicular quality. Clinical and Experimental Reproductive Medicine, 49(2), 93.
Mouse Anti-AMH Recombinant Antibody (CBYC-A557) in IF
Representative confocal images of secondary follicles from multi-dose saline and 5FU treated ovaries 6, 12 and 36 hours following treatment. Sections were fluorescently labelled for with DAPI (blue), AMH (green), Cleaved-Caspase 3 (CC3, red), TUNEL (cyan). n= 3-5 ovaries per cohort, 5 sections analysed per ovary. Scale bar = 50µm. ...View More
Stringer, J. M., Swindells, E. O., Zerafa, N., Liew, S. H., & Hutt, K. J. (2018). Multidose 5-fluorouracil is highly toxic to growing ovarian follicles in mice. Toxicological Sciences, 166(1), 97-107.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYC-A557
Antibody Isotype
IgG1, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 541-560 at the C-terminus of MIS of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Anti-Mullerian Hormone
Introduction
AMH is a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expres
Entrez Gene ID
268
UniProt ID
P03971
Alternative Names
Anti-Mullerian Hormone; Muellerian-Inhibiting Substance; Anti-Muellerian Hormone; MIF; MIS; Mullerian Inhibiting Substance; Muellerian-Inhibiting Factor; Mullerian Inhibiting Factor;
Function
This glycoprotein, produced by the Sertoli cells of the testis, causes regression of the Muellerian duct. It is also able to inhibit the growth of tumors derived from tissues of Muellerian duct origin.
Biological Process
Aging Source: Ensembl
BMP signaling pathway Source: Reactome
Cell-cell signaling Source: ProtInc
Gonadal mesoderm development Source: UniProtKB-KW
Mullerian duct regression Source: UniProtKB
Negative regulation of ovarian follicle development Source: Ensembl
Positive regulation of gene expression Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: Ensembl
Preantral ovarian follicle growth Source: Ensembl
Response to drug Source: Ensembl
Response to organic cyclic compound Source: Ensembl
Sex determination Source: ProtInc
Sex differentiation Source: UniProtKB
Urogenital system development Source: GO_Central
Cellular Location
Secreted
Involvement in disease
Persistent Muellerian duct syndrome 1 (PMDS1): A form of male pseudohermaphroditism characterized by a failure of Muellerian duct regression in otherwise normal males.
More Infomation

Moolhuijsen, L. M., & Visser, J. A. (2020). Anti-Müllerian hormone and ovarian reserve: Update on assessing ovarian function. The Journal of Clinical Endocrinology & Metabolism, 105(11), 3361-3373.

Hoyos, L. R., Visser, J. A., McLuskey, A., Chazenbalk, G. D., Grogan, T. R., & Dumesic, D. A. (2020). Loss of anti-Müllerian hormone (AMH) immunoactivity due to a homozygous AMH gene variant rs10417628 in a woman with classical polycystic ovary syndrome (PCOS). Human Reproduction, 35(10), 2294-2302.

Huang, X., Xu, X., Dai, Y., Cheng, Z., Zheng, X., & Huo, X. (2020). Association of prenatal exposure to PAHs with anti-Müllerian hormone (AMH) levels and birth outcomes of newborns. Science of the Total Environment, 723, 138009.

Zhang, Z., Zhu, B., Chen, W., & Ge, W. (2020). Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish. Molecular and Cellular Endocrinology, 110963.

Xu, H. Y., Zhang, H. X., Xiao, Z., Qiao, J., & Li, R. (2019). Regulation of anti-Müllerian hormone (AMH) in males and the associations of serum AMH with the disorders of male fertility. Asian journal of andrology, 21(2), 109.

Yan, Y. L., Batzel, P., Titus, T., Sydes, J., Desvignes, T., BreMiller, R., ... & Postlethwait, J. H. (2019). A hormone that lost its receptor: anti-Müllerian hormone (AMH) in zebrafish gonad development and sex determination. Genetics, 213(2), 529-553.

Abbara, A., Eng, P. C., Phylactou, M., Clarke, S. A., Hunjan, T., Roberts, R., ... & Dhillo, W. S. (2019). Anti-Müllerian hormone (AMH) in the diagnosis of menstrual disturbance due to polycystic ovarian syndrome. Frontiers in endocrinology, 10, 656.

Sova, H., Unkila-Kallio, L., Tiitinen, A., Hippeläinen, M., Perheentupa, A., Tinkanen, H., ... & Morin-Papunen, L. (2019). Hormone profiling, including anti-Müllerian hormone (AMH), for the diagnosis of polycystic ovary syndrome (PCOS) and characterization of PCOS phenotypes. Gynecological Endocrinology, 35(7), 595-600.

Stracquadanio, M., Ciotta, L., & Palumbo, M. A. (2018). Relationship between serum anti-Mullerian hormone and intrafollicular AMH levels in PCOS women. Gynecological Endocrinology, 34(3), 223-228.

Kruszyńska, A., & Słowińska-Srzednicka, J. (2017). Anti-Müllerian hormone (AMH) as a good predictor of time of menopause. Przeglad menopauzalny= Menopause review, 16(2), 47.

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For research use only. Not intended for any clinical use.

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