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Mouse Anti-ALPI Recombinant Antibody (AP1B9) (CBMAB-A2412-YC)


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Summary

Host Animal
Mouse
Specificity
Cattle
Clone
AP1B9
Antibody Isotype
IgG1, κ
Application
IF

Basic Information

Immunogen
Calf intestinal phosphatase.
Host Species
Mouse
Specificity
Cattle
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Alkaline Phosphatase, Intestinal
Introduction
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a comp
Entrez Gene ID
Human248
Cattle280993
UniProt ID
HumanP09923
CattleP19111
Alternative Names
Alkaline Phosphatase, Intestinal; Intestinal Alkaline Phosphatase; EC 3.1.3.1; IAP; Intestinal-Type Alkaline Phosphatase; Alkaline Phosphomonoesterase; Glycerophosphatase; Kasahara Isozyme;
Biological Process
Dephosphorylation Source: UniProtKB
Digestion Source: Reactome
Phosphatidic acid biosynthetic process Source: Reactome
Cellular Location
Cell membrane
More Infomation

Lallès, J. P. (2020). Intestinal alkaline phosphatase in the gastrointestinal tract of fish: biology, ontogeny, and environmental and nutritional modulation. Reviews in Aquaculture, 12(2), 555-581.

Jiang, Y., Li, X., & Walt, D. R. (2020). Single‐molecule analysis determines isozymes of human alkaline phosphatase in serum. Angewandte Chemie International Edition, 59(41), 18010-18015.

Plaeke, P., De Man, J. G., Smet, A., Malhotra‐Kumar, S., Pintelon, I., Timmermans, J. P., ... & De Winter, B. Y. (2020). Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)‐induced mouse model for sepsis. Neurogastroenterology & Motility, 32(3), e13754.

Takeuchi, A., Hisamatsu, K., Okumura, N., Sugimitsu, Y., Yanase, E., Ueno, Y., & Nagaoka, S. (2020). IIAEK targets intestinal alkaline phosphatase (IAP) to improve cholesterol metabolism with a specific activation of IAP and downregulation of abca1. Nutrients, 12(9), 2859.

Lallès, J. P. (2019). Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition. Nutrition reviews, 77(10), 710-724.

Ishige, T., Itoga, S., Utsuno, E., Nishimura, M., Yoshikawa, M., Kato, N., ... & Nomura, F. (2018). Variant in C-terminal region of intestinal alkaline phosphatase associated with benign familial hyperphosphatasaemia. Journal of medical genetics, 55(10), 701-704.

Parlato, M., Charbit‐Henrion, F., Pan, J., Romano, C., Duclaux‐Loras, R., Le Du, M. H., ... & Cerf‐Bensussan, N. (2018). Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis. EMBO molecular medicine, 10(4), e8483.

Noda, S., Yamada, A., Nakaoka, K., & Goseki-Sone, M. (2017). 1-alpha, 25-Dihydroxyvitamin D3 up-regulates the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis. Nutrition Research, 46, 59-67.

Wu, M., Wang, J., Wang, Z., Zhao, J., Hu, Y., & Chen, X. (2017). Sequence and functional analysis of intestinal alkaline phosphatase from Lateolabrax maculatus. Fish physiology and biochemistry, 43(6), 1463-1476.

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For research use only. Not intended for any clinical use.

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