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Rabbit Anti-ALPI Recombinant Antibody (01) (CBMAB-A2405-YC)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
01
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human ALPI protein
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Alkaline Phosphatase, Intestinal
Introduction
There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal alkaline phosphatase gene encodes a digestive brush-border enzyme. This enzyme is a comp
Entrez Gene ID
248
UniProt ID
P09923
Alternative Names
Alkaline Phosphatase, Intestinal; Intestinal Alkaline Phosphatase; EC 3.1.3.1; IAP; Intestinal-Type Alkaline Phosphatase; Alkaline Phosphomonoesterase; Glycerophosphatase; Kasahara Isozyme;
Biological Process
Dephosphorylation Source: UniProtKB
Digestion Source: Reactome
Phosphatidic acid biosynthetic process Source: Reactome
Cellular Location
Cell membrane
More Infomation

Lallès, J. P. (2020). Intestinal alkaline phosphatase in the gastrointestinal tract of fish: biology, ontogeny, and environmental and nutritional modulation. Reviews in Aquaculture, 12(2), 555-581.

Jiang, Y., Li, X., & Walt, D. R. (2020). Single‐molecule analysis determines isozymes of human alkaline phosphatase in serum. Angewandte Chemie International Edition, 59(41), 18010-18015.

Plaeke, P., De Man, J. G., Smet, A., Malhotra‐Kumar, S., Pintelon, I., Timmermans, J. P., ... & De Winter, B. Y. (2020). Effects of intestinal alkaline phosphatase on intestinal barrier function in a cecal ligation and puncture (CLP)‐induced mouse model for sepsis. Neurogastroenterology & Motility, 32(3), e13754.

Takeuchi, A., Hisamatsu, K., Okumura, N., Sugimitsu, Y., Yanase, E., Ueno, Y., & Nagaoka, S. (2020). IIAEK targets intestinal alkaline phosphatase (IAP) to improve cholesterol metabolism with a specific activation of IAP and downregulation of abca1. Nutrients, 12(9), 2859.

Lallès, J. P. (2019). Recent advances in intestinal alkaline phosphatase, inflammation, and nutrition. Nutrition reviews, 77(10), 710-724.

Ishige, T., Itoga, S., Utsuno, E., Nishimura, M., Yoshikawa, M., Kato, N., ... & Nomura, F. (2018). Variant in C-terminal region of intestinal alkaline phosphatase associated with benign familial hyperphosphatasaemia. Journal of medical genetics, 55(10), 701-704.

Parlato, M., Charbit‐Henrion, F., Pan, J., Romano, C., Duclaux‐Loras, R., Le Du, M. H., ... & Cerf‐Bensussan, N. (2018). Human ALPI deficiency causes inflammatory bowel disease and highlights a key mechanism of gut homeostasis. EMBO molecular medicine, 10(4), e8483.

Noda, S., Yamada, A., Nakaoka, K., & Goseki-Sone, M. (2017). 1-alpha, 25-Dihydroxyvitamin D3 up-regulates the expression of 2 types of human intestinal alkaline phosphatase alternative splicing variants in Caco-2 cells and may be an important regulator of their expression in gut homeostasis. Nutrition Research, 46, 59-67.

Wu, M., Wang, J., Wang, Z., Zhao, J., Hu, Y., & Chen, X. (2017). Sequence and functional analysis of intestinal alkaline phosphatase from Lateolabrax maculatus. Fish physiology and biochemistry, 43(6), 1463-1476.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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