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Mouse Anti-ADM Recombinant Antibody (V2-6092) (CBMAB-0037CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-6092
Antibody Isotype
IgM
Application
IF, IHC

Basic Information

Immunogen
Chemically synthesized full length adrenomedullin
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgM
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)1:10-1:500
IHC1:10-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.02% sodium azide
Concentration
2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adrenomedullin
Introduction
The ADM gene encodes for a preprohormone, which is posttranslationally modified to generate 2 biologically active peptides: adrenomedullin and proadrenomedullin N-terminal 20 peptide (PAMP). Expression of these peptides is widespread, and they have several functions, including vasodilatation, bronchodilatation, hormone secretion regulation, growth modulation, angiogenesis promotion, and antimicrobial activity, among others. AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration.
Entrez Gene ID
133
UniProt ID
P35318
Alternative Names
ADM; adrenomedullin; AM; PAM
Function
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Adrenomedullin receptor signaling pathway
Aging
Amylin receptor signaling pathway
Androgen metabolic process
Animal organ regeneration
Antibacterial humoral response
Antimicrobial humoral immune response mediated by antimicrobial peptide
Branching involved in labyrinthine layer morphogenesis
Defense response to Gram-negative bacterium
Defense response to Gram-positive bacterium
Developmental growth
Female pregnancy Source: Ensembl
G protein-coupled receptor internalization
G protein-coupled receptor signaling pathway
Heart development
Hormone secretion
Inflammatory response
Negative regulation of cell population proliferation
Negative regulation of inflammatory response to antigenic stimulus
Negative regulation of vascular permeability
Negative regulation of vasoconstriction
Neural tube closure
Neuron projection regeneration
Odontogenesis of dentin-containing tooth
Positive regulation of angiogenesis
Positive regulation of apoptotic process
Positive regulation of cell population proliferation
Positive regulation of cytosolic calcium ion concentration
Positive regulation of heart rate
Positive regulation of progesterone biosynthetic process
Positive regulation of vasculogenesis
Receptor internalization
Regulation of systemic arterial blood pressure
Regulation of the force of heart contraction
Regulation of urine volume
Response to cold
Response to glucocorticoid
Response to hypoxia
Response to insulin
Response to lipopolysaccharide
Response to starvation
Response to wounding
Signal transduction
Spongiotrophoblast layer development
Vascular associated smooth muscle cell development
Vasculogenesis
Cellular Location
Secreted
More Infomation

Hupf, J., Mustroph, J., Hanses, F., Evert, K., Maier, L. S., & Jungbauer, C. G. (2020). RNA-expression of adrenomedullin is increased in patients with severe COVID-19. Critical Care, 24(1), 1-3.

Wilson, D. C., Schefold, J. C., Baldirà, J., Spinetti, T., Saeed, K., & Elke, G. (2020). Adrenomedullin in COVID-19 induced endotheliitis. Critical care, 24(1), 1-2.

Paré, M., Darini, C. Y., Yao, X., Chignon-Sicard, B., Rekima, S., Lachambre, S., ... & Ladoux, A. (2020). Breast cancer mammospheres secrete Adrenomedullin to induce lipolysis and browning of adjacent adipocytes. BMC cancer, 20(1), 1-15.

Lundberg, O. H., Lengquist, M., Spångfors, M., Annborn, M., Bergmann, D., Schulte, J., ... & Friberg, H. (2020). Circulating bioactive adrenomedullin as a marker of sepsis, septic shock and critical illness. Critical Care, 24(1), 1-10.

Ma, F., Chen, G., Rodriguez, E. L., Klein, J. D., Sands, J. M., & Wang, Y. (2020). Adrenomedullin inhibits osmotic water permeability in rat inner medullary collecting ducts. Cells, 9(12), 2533.

Voors, A. A., Kremer, D., Geven, C., Ter Maaten, J. M., Struck, J., Bergmann, A., ... & Butler, J. (2019). Adrenomedullin in heart failure: pathophysiology and therapeutic application. European journal of heart failure, 21(2), 163-171.

Ter Maaten, J. M., Kremer, D., Demissei, B. G., Struck, J., Bergmann, A., Anker, S. D., ... & Voors, A. A. (2019). Bio‐adrenomedullin as a marker of congestion in patients with new‐onset and worsening heart failure. European journal of heart failure, 21(6), 732-743.

Kim, H., Hur, M., Struck, J., Bergmann, A., & Di Somma, S. (2019). Circulating biologically active adrenomedullin predicts organ failure and mortality in sepsis. Annals of laboratory medicine, 39(5), 454-463.

Mebazaa, A., Geven, C., Hollinger, A., Wittebole, X., Chousterman, B. G., Blet, A., ... & Laterre, P. F. (2018). Circulating adrenomedullin estimates survival and reversibility of organ failure in sepsis: the prospective observational multinational Adrenomedullin and Outcome in Sepsis and Septic Shock-1 (AdrenOSS-1) study. Critical care, 22(1), 1-12.

Caironi, P., Latini, R., Struck, J., Hartmann, O., Bergmann, A., Maggio, G., ... & Spanuth, E. (2017). Circulating biologically active adrenomedullin (bio-ADM) predicts hemodynamic support requirement and mortality during sepsis. Chest, 152(2), 312-320.

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For research use only. Not intended for any clinical use.

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