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Mouse Anti-ADGRE5 Recombinant Antibody (V2-360335) (CBMAB-C2088-CQ)


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Published Data
Mouse Anti-ADGRE5 Recombinant Antibody (VIM3b) (CBMAB-C2088-CQ) in FC
Flow cytometry analysis of HuAR2T.rKSHV.219 Cas9 cells untreated or treated with reactivation mix and stained with the indicated antibody. ...View More
Gabaev, I., Williamson, J. C., Crozier, T. W., Schulz, T. F., & Lehner, P. J. (2020). Quantitative proteomics analysis of lytic KSHV infection in human endothelial cells reveals targets of viral immune modulation. Cell Reports, 33(2), 108249.
Mouse Anti-ADGRE5 Recombinant Antibody (VIM3b) (CBMAB-C2088-CQ) in ICC
Differentiation of hMSCs towards the adipogenic or osteogenic lineage.
A+B. Immunocytochemistry after 1 week of differentiation. Nuclei were visualized with DAPI. C+D. Flow cytometry after 2 weeks. The change in the mean fluorescence intensity (MFI) before and after differentiation was calculated taking hMSCs as a reference. At least three independent experiments were performed. Black: hMSCs; red: differentiated cells. Shown are representative stainings. ...View More
Niehage, C., Steenblock, C., Pursche, T., Bornhäuser, M., Corbeil, D., & Hoflack, B. (2011). The cell surface proteome of human mesenchymal stromal cells. PloS one, 6(5), e20399.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-360335
Antibody Isotype
IgG1
Application
IHC-F, WB

Basic Information

Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
ABS
Preservative
< 0.09% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor E5
Introduction
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.
Entrez Gene ID
976
UniProt ID
P48960
Alternative Names
Adhesion G Protein-Coupled Receptor E5; Leukocyte Antigen CD97; CD97 Antigen; Seven-Transmembrane, Heterodimeric Receptor Associated With Inflammation; Seven Transmembrane Helix Receptor; Seven-Span Transmembrane Protein; CD97 Molecule; TM7LN1; CD97;
Function
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell-cell signaling
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Immune response
Inflammatory response
Neutrophil degranulation
Cellular Location
Cell membrane
Adhesion G protein-coupled receptor E5 subunit alpha: Extracellular space
Topology
Extracellular: 21-552 aa
Helical: 553-572 aa
Cytoplasmic: 573-581 aa
Helical: 582-601 aa
Extracellular: 602-620 aa
Helical: 621-642 aa
Cytoplasmic: 643-653 aa
Helical: 654-674 aa
Extracellular: 675-691 aa
Helical: 692-712 aa
Cytoplasmic: 713-739 aa
Helical: 740-760 aa
Extracellular: 761-766 aa
Helical: 767-789 aa
Cytoplasmic: 790-835 aa
PTM
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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