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Mouse Anti-ADGRE5 Recombinant Antibody (V2-183826) (CBMAB-C1834-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-183826
Antibody Isotype
IgG
Application
ELISA, ICC/IF, IF

Basic Information

Immunogen
Recombinant Human CD97 protein
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:1,000-1:2,000
IF(ICC)1:20-1:100

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Adhesion G Protein-Coupled Receptor E5
Introduction
This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
Entrez Gene ID
976
UniProt ID
P48960
Alternative Names
Adhesion G Protein-Coupled Receptor E5; Leukocyte Antigen CD97; CD97 Antigen; Seven-Transmembrane, Heterodimeric Receptor Associated With Inflammation; Seven Transmembrane Helix Receptor; Seven-Span Transmembrane Protein; CD97 Molecule; TM7LN1; CD97;
Function
Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell adhesion
Cell-cell signaling
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Immune response
Inflammatory response
Neutrophil degranulation
Cellular Location
Cell membrane
Adhesion G protein-coupled receptor E5 subunit alpha: Extracellular space
Topology
Extracellular: 21-552 aa
Helical: 553-572 aa
Cytoplasmic: 573-581 aa
Helical: 582-601 aa
Extracellular: 602-620 aa
Helical: 621-642 aa
Cytoplasmic: 643-653 aa
Helical: 654-674 aa
Extracellular: 675-691 aa
Helical: 692-712 aa
Cytoplasmic: 713-739 aa
Helical: 740-760 aa
Extracellular: 761-766 aa
Helical: 767-789 aa
Cytoplasmic: 790-835 aa
PTM
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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