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Mouse Anti-ADGRE3 (AA 1-652) Recombinant Antibody (V2-43346) (CBMAB-E0249-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-43346
Antibody Isotype
IgG2b
Application
IHC-F, MC

Basic Information

Immunogen
NS0 mouse myeloma cell line transfected with human EMR3, Met1-Tyr652
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
FC0.25 μg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-652

Target

Full Name
Adhesion G Protein-Coupled Receptor E3
Introduction
This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms.
Entrez Gene ID
84658
UniProt ID
Q9BY15
Alternative Names
Adhesion G Protein-Coupled Receptor E3; Egf-Like Module Containing, Mucin-Like, Hormone Receptor-Like 3; EGF-Like Module-Containing Mucin-Like Hormone Receptor-Like 3; EGF-Like Module Receptor 3; EMR3; Egf-Like Module-Containing Mucin-Like Receptor 3
Function
Orphan receptor that may play a role myeloid-myeloid interactions during immune and inflammatory responses. A ligand for the soluble form of this receptor is present at the surface of monocytes-derived macrophages and activated neutrophils.
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway
Cell surface receptor signaling pathway
G protein-coupled receptor signaling pathway
Neutrophil degranulation
Cellular Location
Cell membrane
Isoform 3: Secreted
Topology
Extracellular: 22-357 aa
Helical: 358-378 aa
Cytoplasmic: 379-389 aa
Helical: 390-410 aa
Extracellular: 411-416 aa
Helical: 417-437 aa
Cytoplasmic: 438-464 aa
Helical: 465-485 aa
Extracellular: 486-508 aa
Helical: 509-529 aa
Cytoplasmic: 530-557 aa
Helical: 558-578 aa
Extracellular: 579-580 aa
Helical: 581-601 aa
Cytoplasmic: 602-652 aa
PTM
Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
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For research use only. Not intended for any clinical use.

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