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Mouse Anti-ADAMTS4 Recombinant Antibody (V2-6084) (CBMAB-0029CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-6084
Antibody Isotype
IgG2
Application
Neutralization, WB

Basic Information

Immunogen
Human recombinant ADAMTS4
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
None
Concentration
0.5 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4
Introduction
ADAMTS4 is a member of the large ADAMTS family of zinc-dependent proteases. For a general description of the ADAMTS gene family, see ADAMTS1. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Pratta et al. (2003) studied the production of ADAMTS4 in monolayer chondrocytes, capsular fibroblasts, and cartilage. They concluded that ADAMTS4 is constitutively produced in these cells and this tissue, and that stimulation by interleukin-1 (147760, 147720) results in aggrecanase activation.
Entrez Gene ID
9507
UniProt ID
O75173
Alternative Names
ADAMTS4; ADAM metallopeptidase with thrombospondin type 1 motif 4; ADMP-1; ADAMTS-2; ADAMTS-4
Function
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Biological Process
Extracellular matrix disassembly
Extracellular matrix organization
Proteolysis
Skeletal system development
Cellular Location
Extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
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For research use only. Not intended for any clinical use.

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