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Mouse Anti-ADAMTS4 Recombinant Antibody (V2-179850) (CBMAB-A1215-YC)


See all ADAMTS4 antibodies
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Published Data
Mouse Anti-ADAMTS4 Recombinant Antibody (CBYC-A329) (CBMAB-A1215-YC) in WB
The protein levels of COL2A1 and ADAMTS3 were quantified by western blot. ...View More
Zhang, M., Mou, L., Liu, S., Sun, F., & Gong, M. (2021). Circ_0001103 alleviates IL-1β-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375. Clinical Immunology, 227, 108718.

Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-179850
Antibody Isotype
IgG1, κ
Application
WB

Basic Information

Immunogen
Raised against recombinant ADAMTS-4 of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, 0.1% gelatin.
Preservative
< 0.1% sodium azide
Concentration
0.1 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4
Introduction
ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like
Entrez Gene ID
9507
UniProt ID
O75173
Alternative Names
ADAM Metallopeptidase With Thrombospondin Type 1 Motif 4; A Disintegrin-Like And Metalloprotease (Reprolysin Type) With Thrombospondin Type 1 Motif, 4; Aggrecanase-1; EC 3.4.24.82; ADAM-TS 4; ADAMTS-4; ADAM-TS4;
Function
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Biological Process
Extracellular matrix disassembly
Extracellular matrix organization
Proteolysis
Skeletal system development
Cellular Location
Extracellular matrix
PTM
The precursor is cleaved by a furin endopeptidase.
Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X2-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).
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For research use only. Not intended for any clinical use.

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