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Mouse Anti-AAAS Recombinant Antibody (V2-178851) (CBMAB-A0068-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
V2-178851
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa1-101 from AAAS (NP_056480) with GST tag.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IHC3 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Buffer
PBS, pH7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
achalasia, adrenocortical insufficiency, alacrimia (Allgrove, triple-A)
Introduction
AAAS is a member of the WD-repeat family of regulatory proteins and may be involved in normal development of the peripheral and central nervous system. The encoded protein is part of the nuclear pore complex and is anchored there by NDC1. Defects in this
Entrez Gene ID
Human8086
Mouse223921
Rat300259
UniProt ID
HumanQ9NRG9
MouseP58742
Alternative Names
Aladin WD Repeat Nucleoporin; Adracalin; Achalasia, Adrenocortical Insufficiency, Alacrimia; Allgrove, Triple-A; ADRACALA; Aladin;
Function
Plays a role in the normal development of the peripheral and central nervous system (PubMed:11062474. Required for the correct localization of aurora kinase AURKA and the microtubule minus end-binding protein NUMA1 as well as a subset of AURKA targets which ensures proper spindle formation and timely chromosome alignment.
Biological Process
Fertilization
Intracellular transport of virus
Learning
Microtubule bundle formation
Mitotic spindle assembly
mRNA export from nucleus
Nucleocytoplasmic transport
Protein sumoylation
Regulation of cellular response to heat
Regulation of gene silencing by miRNA
Regulation of glycolytic process
Regulation of nucleocytoplasmic transport
tRNA export from nucleus
Viral life cycle
Viral process
Viral transcription
Cellular Location
Nuclear pore complex; Nucleus envelope; Spindle pole. In metaphase cells localizes within the spindle with some accumulation around spindle poles, with the highest concentration between the centrosome and metaphase plate. The localization to the spindle is microtubule-mediated.
Involvement in disease
An autosomal recessive disorder characterized by adreno-corticotropic hormone (ACTH)-resistant adrenal failure, achalasia of the esophageal cardia and alacrima. The syndrome is associated with variable and progressive neurological impairment involving the central, peripheral, and autonomic nervous system. Other features such as palmoplantar hyperkeratosis, short stature, facial dysmorphy and osteoporosis may also be present.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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