Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

AKT1 Matched Antibody Pair (058) (APMAB-058LY)


See all AKT1 antibodies
Online Inquiry

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-AKT1 polyclonal antibody, 100 ug
Detection Antibody
Anti-AKT1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Alternative Names
AKT Serine/Threonine Kinase 1; V-Akt Murine Thymoma Viral Oncogene Homolog 1; Protein Kinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; PKB; RAC; V-Akt Murine Thymoma Viral Oncogene-Like Protein 1; RAC-Alpha Serine/Threonine-Protein Kinase;
Entrez Gene ID
207
UniProt ID
P31749
More Infomation

Zhao, J., & Zeng, Z. (2020). Combined effects of AKT serine/threonine kinase 1 polymorphisms and environment on congenital heart disease risk: A case-control study. Medicine, 99(26).

Bozgeyik, I., & Karadag, A. (2020). The role of miR-125b-5p-AKT serine/threonine kinase 1 axis in osteosarcoma. Gene Reports, 21, 100935.

Sukmanadi, M., Sudjarwo, S. A., Effendi, M. H., Srianto, P., Madyawati, R. S. P., Lamid, M., & Plumeriastuti, H. (2020). Capsaicin Bioactive in Cabai (Capsicum Annum L.) as Anticancer Through Inhibition of over Ekspresi Protein Target RAC-alpha serine/threonine-protein kinase (AKT1) and Mitogen-activated protein kinase 1 (MAPK1) on Hepatocyt Cell Mice (mus musculus). Pharmacognosy Journal, 12(4).

Ou, R., Mo, L., Tang, H., Leng, S., Zhu, H., Zhao, L., ... & Xu, Y. (2020). circRNA-AKT1 sequesters miR-942-5p to upregulate AKT1 and promote cervical cancer progression. Molecular Therapy-Nucleic Acids, 20, 308-322.

Sukhorukov, V. S., Baranich, T. I., Atochin, D. N., & Glinkina, V. V. (2018). The Adaptation Role of Serine/Threonine Kinase Akt1 in Anabolism of Muscular Tissue. Biology Bulletin Reviews, 8(6), 489-496.

Zhang, T., Huang, J., Yi, Y., Zhang, X., Loor, J. J., Cao, Y., ... & Luo, J. (2018). Akt serine/threonine kinase 1 regulates de novo fatty acid synthesis through the mammalian target of rapamycin/sterol regulatory element binding protein 1 axis in dairy goat mammary epithelial cells. Journal of agricultural and food chemistry, 66(5), 1197-1205.

Yao, J., Zhang, P., Li, J., & Xu, W. (2017). MicroRNA-215 acts as a tumor suppressor in breast cancer by targeting AKT serine/threonine kinase 1. Oncology letters, 14(1), 1097-1104.

Cai, K., Wang, B., Dou, H., Luan, R., Bao, X., & Chu, J. (2017). IL-17A promotes the proliferation of human nasopharyngeal carcinoma cells through p300-mediated Akt1 acetylation. Oncology letters, 13(6), 4238-4244.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used AKT1 Matched Antibody Pair (058)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quoteOnline Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry