AKR1C2 Matched Antibody Pair (052) (APMAB-052LY)

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Datasheet

Specifications

ApplIcation

Sandwich ELISA

Specificity

Human

Capture Antibody

Rabbit anti-AKR1C2 polyclonal antibody, 100 ug

Detection Antibody

Anti-AKR1C2 Mouse polyclonal antibody, 20 ug

Dilutions

10 ng/ml-100 ng/ml

Format

Liquid

Storage

Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.

Introduction

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Alternative Names

Aldo-Keto Reductase Family 1 Member C2; Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III; Trans-1,2-Dihydrobenzene-1,2-Diol Dehydrogenase; Testicular 17,20-Desmolase Deficiency; Chlordecone Reductase Homolog HAKRD; 3-Alpha-HSD3; DD/BABP; DDH2; DD-2; DD2; Aldo-Keto Reductase Family 1, Member C2 (Dihydrodiol Dehydrogenase 2; Bile Acid Binding Protein; 3-Alpha Hydroxysteroid Dehydrogenase, Type III); Dihydrodiol Dehydrogenase/Bile Acid-Binding Protein; Type III 3-Alpha-Hydroxysteroid Dehydrogenase; Type II Dihydrodiol Dehydrogenase; Pseudo-Chlordecone Reductase;

Entrez Gene ID

1646

UniProt ID

P52895

More Infomation

References

Sun, T., Gao, L., Sun, X., Wang, X., Guo, R., & Yu, Y. (2021). Aldo-keto reductase 1C inhibitors could reverse resistance of HepG2 Cis-platin-resistant cells, but not only by inhibiting AKR1Cs, based on transcriptomic and NADH metabolic analysis. bioRxiv.

Franko, A., Berti, L., Hennenlotter, J., Rausch, S., Scharpf, M. O., de Angelis, M. H., ... & Heni, M. (2020). Transcript Levels of Aldo-Keto Reductase Family 1 Subfamily C (AKR1C) Are Increased in Prostate Tissue of Patients with Type 2 Diabetes. Journal of personalized medicine, 10(3), 124.

Jin, Y. X., Zhou, X. F., Chen, Y. Y., Jin, W. X., Wang, Y. H., Ye, D. R., ... & Chen, E. D. (2019). Up-Regulated AKR1C2 is correlated with favorable prognosis in thyroid carcinoma. Journal of Cancer, 10(15), 3543.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

AKR1C2 Matched Antibody Pair (053)

Antibody Pairs

AKR1C2 Matched Antibody Pair (053)

Related Products

AKR1C2 Matched Antibody Pair (053)

Mouse Anti-AKR1C2 Recombinant Antibody (V2-180477)

Mouse Anti-AKR1C2 Recombinant Antibody (V2-49560)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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